Please use this identifier to cite or link to this item: https://doi.org/10.2169/internalmedicine.51.7157
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dc.titleImmunoglobulin-associated creatine kinase masquerading as macro-creatine kinase type 2 in a statin user
dc.contributor.authorLoh, T.P.
dc.contributor.authorAng, Y.H.
dc.contributor.authorNeo, S.F.
dc.contributor.authorYin, C.
dc.contributor.authorWong, M.S.
dc.contributor.authorLeong, S.M.
dc.contributor.authorSaw, S.
dc.contributor.authorSethi, S.K.
dc.date.accessioned2014-10-27T08:31:11Z
dc.date.available2014-10-27T08:31:11Z
dc.date.issued2012
dc.identifier.citationLoh, T.P., Ang, Y.H., Neo, S.F., Yin, C., Wong, M.S., Leong, S.M., Saw, S., Sethi, S.K. (2012). Immunoglobulin-associated creatine kinase masquerading as macro-creatine kinase type 2 in a statin user. Internal Medicine 51 (9) : 1061-1064. ScholarBank@NUS Repository. https://doi.org/10.2169/internalmedicine.51.7157
dc.identifier.issn09182918
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100888
dc.description.abstractMacro-creatine kinase (CK) is a cause of falsely elevated CK. Macro-CK type 1 is immunoglobulinassociated CK; type 2 is polymeric mitochondrial-CK. An elderly asymptomatic lady had an elevated CK level after receiving statin therapy. Her CK gel electrophoresis analysis demonstrated coexisting macro-CK type 1 and type 2 patterns. Further analysis by immunofixation and mixing this patient's serum with CK control material revealed an IgG-associated macro-CK that mimicked the electrophoretic pattern of macro-CK type 2. This highly unusual discovery suggests the possibility of the misinterpretation of macro-CK type 1 as macro-CK type 2. Falsely elevated CK is still common despite modern laboratory instrumentation and should be investigated. © 2012 The Japanese Society of Internal Medicine.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2169/internalmedicine.51.7157
dc.sourceScopus
dc.subjectCreatine kinase
dc.subjectImmunoglobulin-associated
dc.subjectIsoenzyme
dc.subjectMacro-creatine kinase
dc.subjectMitochondrial creatine kinase
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.2169/internalmedicine.51.7157
dc.description.sourcetitleInternal Medicine
dc.description.volume51
dc.description.issue9
dc.description.page1061-1064
dc.description.codenIEDIE
dc.identifier.isiut000304604400012
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