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Title: Germ cell sex prior to meiosis in the rainbow trout
Authors: Li, M. 
Shen, Q.
Wong, F.M.
Xu, H. 
Hong, N.
Zeng, L.
Liu, L.
Wei, Q.
Hong, Y. 
Keywords: boule
germ cell sex
Issue Date: Jan-2011
Citation: Li, M., Shen, Q., Wong, F.M., Xu, H., Hong, N., Zeng, L., Liu, L., Wei, Q., Hong, Y. (2011-01). Germ cell sex prior to meiosis in the rainbow trout. Protein and Cell 2 (1) : 48-54. ScholarBank@NUS Repository.
Abstract: Germ cells make two major decisions when they move from an indeterminate state to their final stage of gamete production. One decision is sexual commitment for sperm or egg production, and the other is to maintain mitotic division or entry into meiosis. It is unclear whether the two decisions are made as a single event or separate events, because there has been no evidence for the presence of germ cell sex prior to meiosis. Here we report direct evidence in the fish rainbow trout that gonia have distinct sexuality. We show that dazl expression occurs in both male and female gonia but exhibits differential intracellular distribution. More strikingly, we show that boule is highly expressed in male gonia but absent in female gonia. Therefore, mitotic gonia possess sex, sperm/egg decision and mitosis/meiosis decision are two independent events, and sperm/egg decision precedes mitosis/meiosis decision in rainbow trout, making this organism a unique vertebrate model for mechanistic understanding of germ cell sex differentiation and relationship between the two decisions. © 2011 Higher Education Press and Springer-Verlag Berlin Heidelberg.
Source Title: Protein and Cell
ISSN: 1674800X
DOI: 10.1007/s13238-011-1003-8
Appears in Collections:Staff Publications

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