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Title: Folic acid-conjugated protein cages of a plant virus: A novel delivery platform for doxorubicin
Authors: Ren, Y. 
Sek, M.W. 
Lim, L.-Y. 
Issue Date: May-2007
Citation: Ren, Y., Sek, M.W., Lim, L.-Y. (2007-05). Folic acid-conjugated protein cages of a plant virus: A novel delivery platform for doxorubicin. Bioconjugate Chemistry 18 (3) : 836-843. ScholarBank@NUS Repository.
Abstract: The protein cage of a plant virus may provide a template for monodispersed nanosized systems for drug delivery. Using the Hibiscus chlorotic ringspot virus (HCRSV) as a model plant virus, we have prepared nanosized protein cages (30 nm) capable of encapsulating the anticancer drug, doxorubicin. The technique utilized the simultaneous encapsulation of a polyprotic acid of mw 200 kDa to produce an encapsulation efficiency for doxorubicin of about 7.5%. Folic acid was conjugated onto the capsids to impart cancer-targeting capability. The resultant nanosized systems improved the uptake and cytotoxicity of doxorubicin in the ovarian cancer cells, OVCAR-3, with statistical significance. Plant virus capsids may therefore provide viable templates for targeted drug delivery in cancer chemotherapy. © 2007 American Chemical Society.
Source Title: Bioconjugate Chemistry
ISSN: 10431802
DOI: 10.1021/bc060361p
Appears in Collections:Staff Publications

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