Please use this identifier to cite or link to this item: https://doi.org/10.1021/bc060361p
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dc.titleFolic acid-conjugated protein cages of a plant virus: A novel delivery platform for doxorubicin
dc.contributor.authorRen, Y.
dc.contributor.authorSek, M.W.
dc.contributor.authorLim, L.-Y.
dc.date.accessioned2014-10-27T08:28:47Z
dc.date.available2014-10-27T08:28:47Z
dc.date.issued2007-05
dc.identifier.citationRen, Y., Sek, M.W., Lim, L.-Y. (2007-05). Folic acid-conjugated protein cages of a plant virus: A novel delivery platform for doxorubicin. Bioconjugate Chemistry 18 (3) : 836-843. ScholarBank@NUS Repository. https://doi.org/10.1021/bc060361p
dc.identifier.issn10431802
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100702
dc.description.abstractThe protein cage of a plant virus may provide a template for monodispersed nanosized systems for drug delivery. Using the Hibiscus chlorotic ringspot virus (HCRSV) as a model plant virus, we have prepared nanosized protein cages (30 nm) capable of encapsulating the anticancer drug, doxorubicin. The technique utilized the simultaneous encapsulation of a polyprotic acid of mw 200 kDa to produce an encapsulation efficiency for doxorubicin of about 7.5%. Folic acid was conjugated onto the capsids to impart cancer-targeting capability. The resultant nanosized systems improved the uptake and cytotoxicity of doxorubicin in the ovarian cancer cells, OVCAR-3, with statistical significance. Plant virus capsids may therefore provide viable templates for targeted drug delivery in cancer chemotherapy. © 2007 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/bc060361p
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1021/bc060361p
dc.description.sourcetitleBioconjugate Chemistry
dc.description.volume18
dc.description.issue3
dc.description.page836-843
dc.description.codenBCCHE
dc.identifier.isiut000246485500030
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