Please use this identifier to cite or link to this item: https://doi.org/10.2174/157340607780059495
Title: Evaluation of Polygonum bistorta for anticancer potential using selected cancer cell lines
Authors: Manoharan, K.P.
Yang, D. 
Hsu, A.
Huat, B.T.K.
Keywords: β-sitosterol
Cancer cell lines
Cycloartane triterpenoids
Cytotoxic activity
MTT assay
Polygonum bistorta
Issue Date: Mar-2007
Citation: Manoharan, K.P.,Yang, D.,Hsu, A.,Huat, B.T.K. (2007-03). Evaluation of Polygonum bistorta for anticancer potential using selected cancer cell lines. Medicinal Chemistry 3 (2) : 121-126. ScholarBank@NUS Repository. https://doi.org/10.2174/157340607780059495
Abstract: The chloroform and hexane fractions and their sub-fractions of Polygonum bistorta (Polygonaceae) were evaluated for their cytotoxic activity against P338 (Murine lymphocytic leukaemia), HepG2 (Hepatocellular carcinoma), J82 (Bladder transitional carcinoma), HL60 (Human leukaemia), MCF7 (Human breast cancer) and LL2 (Lewis lung carcinoma) cancer cell lines in culture. Both the chloroform and hexane fractions and a few of their sub-fractions showed moderate to very good activity against P388, HL60 and LL2 cancer cell lines. Both active and non-active fractions were further investigated for their chemical constituents. A total of nine compounds, viz. 24(E)-ethylidenecycloartanone (1), 24(E)-ethylidenecycloartan-3α-ol (2), cycloartane-3,24-dione (3), 24-methylenecycloartanone (4), friedelin (5), 3β-friedelinol (6), β-sitosterol (7), γ-sitosterol (8) and β-sitosterone (9) were isolated. One of the pure compounds, 24(E)-ethylidenecycloartanone 1, which was obtained in sufficient quantity, was tested for its cytotoxicity against P388, LL2, HL60 and WEHI164 (Murine fibrosarcoma) cancer cell lines but was found to have no activity even at a concentration of 100 μg/mL. © 2007 Bentham Science Publishers Ltd.
Source Title: Medicinal Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/100615
ISSN: 15734064
DOI: 10.2174/157340607780059495
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