Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis

Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol200100e

Title:	Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis
Authors:	Minami, A. Migita, A. Inada, D. Hotta, K. Watanabe, K. Oguri, H. Oikawa, H.
Issue Date:	1-Apr-2011
Citation:	Minami, A., Migita, A., Inada, D., Hotta, K., Watanabe, K., Oguri, H., Oikawa, H. (2011-04-01). Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis. Organic Letters 13 (7) : 1638-1641. ScholarBank@NUS Repository. https://doi.org/10.1021/ol200100e
Abstract:	Our recent findings of the first epoxide hydrolase Lsd19, involved in lasalocid A biosynthesis, led us to investigate a long-standing controversial issue on the mechanism of enzymatic epoxide-opening cascades. The site-directed mutagenesis and domain dissection analysis to reveal the mechanism of the reaction catalyzed by Lsd19 is examined, especially in the role of acidic amino acid pair and catalytic domains. © 2011 American Chemical Society.
Source Title:	Organic Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/100593
ISSN:	15237060
DOI:	10.1021/ol200100e
Appears in Collections:	Staff Publications

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