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|Title:||Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis||Authors:||Minami, A.
|Issue Date:||1-Apr-2011||Citation:||Minami, A., Migita, A., Inada, D., Hotta, K., Watanabe, K., Oguri, H., Oikawa, H. (2011-04-01). Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis. Organic Letters 13 (7) : 1638-1641. ScholarBank@NUS Repository. https://doi.org/10.1021/ol200100e||Abstract:||Our recent findings of the first epoxide hydrolase Lsd19, involved in lasalocid A biosynthesis, led us to investigate a long-standing controversial issue on the mechanism of enzymatic epoxide-opening cascades. The site-directed mutagenesis and domain dissection analysis to reveal the mechanism of the reaction catalyzed by Lsd19 is examined, especially in the role of acidic amino acid pair and catalytic domains. © 2011 American Chemical Society.||Source Title:||Organic Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/100593||ISSN:||15237060||DOI:||10.1021/ol200100e|
|Appears in Collections:||Staff Publications|
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