Please use this identifier to cite or link to this item: https://doi.org/10.1038/ni.1780
Title: Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation
Authors: Fallang, L.-E.
Bergseng, E.
Hotta, K. 
Berg-Larsen, A.
Kim, C.-Y. 
Sollid, L.M.
Issue Date: 2009
Citation: Fallang, L.-E., Bergseng, E., Hotta, K., Berg-Larsen, A., Kim, C.-Y., Sollid, L.M. (2009). Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation. Nature Immunology 10 (10) : 1096-1101. ScholarBank@NUS Repository. https://doi.org/10.1038/ni.1780
Abstract: Celiac disease driven by an antigluten T cell response is strongly associated with the histocompatibility antigen HLA-DQ2.5 but is barely associated with HLA-DQ2.2. Yet these molecules have very similar peptide-binding motifs and both present gluten T cell epitopes. We found that DQ2.5+ antigen-presenting cells (APCs) had greater stability of bound peptides and protracted gluten presentation relative to that of DQ2.2+ cells. The improved ability of DQ2.5 to retain its peptide cargo can be ascribed to a polymorphism of DQα22 whereby DQ2.5 (tyrosine) can establish a hydrogen bond to the peptide main chain but DQ2.2 (phenylalanine) cannot. Our findings suggest that the kinetic stability of complexes of peptide and major histocompatibility complex (MHC) is of importance for the association of HLA with disease.
Source Title: Nature Immunology
URI: http://scholarbank.nus.edu.sg/handle/10635/100454
ISSN: 15292908
DOI: 10.1038/ni.1780
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

88
checked on Oct 16, 2019

WEB OF SCIENCETM
Citations

77
checked on Oct 16, 2019

Page view(s)

47
checked on Oct 12, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.