Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.bjp.0701995
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dc.titleAnti-nociceptive responses produced by human putative counterpart of nocistatin
dc.contributor.authorMinami, T.
dc.contributor.authorOkuda-Ashitaka, E.
dc.contributor.authorNishiuchi, Y.
dc.contributor.authorKimura, T.
dc.contributor.authorTachibana, S.
dc.contributor.authorMori, H.
dc.contributor.authorIto, S.
dc.date.accessioned2014-10-27T08:22:00Z
dc.date.available2014-10-27T08:22:00Z
dc.date.issued1998
dc.identifier.citationMinami, T., Okuda-Ashitaka, E., Nishiuchi, Y., Kimura, T., Tachibana, S., Mori, H., Ito, S. (1998). Anti-nociceptive responses produced by human putative counterpart of nocistatin. British Journal of Pharmacology 124 (6) : 1016-1018. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.bjp.0701995
dc.identifier.issn00071188
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100100
dc.description.abstractb-nocistatin is a heptadecapeptide produced from bovine prepronociceptin and blocks the induction of hyperalgesia and touch-evoked pain (allodynia) by intrathecal administration of nociceptin or prostaglandin E2 (PGE2). Human prepronociceptin may generate a 30-amino acid peptide different in length from b-nocistatin. Here, we examine whether the human putative counterpart of nocistatin (h-nocistatin) possessed the same biological activities as b-nocistatin. Simultaneous intrathecal injection of h-nocistatin in mice blocked the induction of allodynia by nociceptin and PGE2 in a dose-dependent manner with ID50 values of 329 pg kg-1 and 16.6 ng kg-1, respectively. h-nocistatin was about 10 times less potent than b-nocistatin. h-nocistatin also attenuated the nociceptin- and PGE2-induced hyperalgesia. These results demonstrate that h-nocistatin is biologically active and may be involved in the processing of pain at the spinal level in humans.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/sj.bjp.0701995
dc.sourceScopus
dc.subjectAllodynia
dc.subjectHyperalgesia
dc.subjectNociceptin/orphanin FQ
dc.subjectProstaglandin E2
dc.subjectSpinal cord
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1038/sj.bjp.0701995
dc.description.sourcetitleBritish Journal of Pharmacology
dc.description.volume124
dc.description.issue6
dc.description.page1016-1018
dc.description.codenBJPCB
dc.identifier.isiut000074965000002
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