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https://doi.org/10.1038/sj.bjp.0701995
DC Field | Value | |
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dc.title | Anti-nociceptive responses produced by human putative counterpart of nocistatin | |
dc.contributor.author | Minami, T. | |
dc.contributor.author | Okuda-Ashitaka, E. | |
dc.contributor.author | Nishiuchi, Y. | |
dc.contributor.author | Kimura, T. | |
dc.contributor.author | Tachibana, S. | |
dc.contributor.author | Mori, H. | |
dc.contributor.author | Ito, S. | |
dc.date.accessioned | 2014-10-27T08:22:00Z | |
dc.date.available | 2014-10-27T08:22:00Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | Minami, T., Okuda-Ashitaka, E., Nishiuchi, Y., Kimura, T., Tachibana, S., Mori, H., Ito, S. (1998). Anti-nociceptive responses produced by human putative counterpart of nocistatin. British Journal of Pharmacology 124 (6) : 1016-1018. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.bjp.0701995 | |
dc.identifier.issn | 00071188 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/100100 | |
dc.description.abstract | b-nocistatin is a heptadecapeptide produced from bovine prepronociceptin and blocks the induction of hyperalgesia and touch-evoked pain (allodynia) by intrathecal administration of nociceptin or prostaglandin E2 (PGE2). Human prepronociceptin may generate a 30-amino acid peptide different in length from b-nocistatin. Here, we examine whether the human putative counterpart of nocistatin (h-nocistatin) possessed the same biological activities as b-nocistatin. Simultaneous intrathecal injection of h-nocistatin in mice blocked the induction of allodynia by nociceptin and PGE2 in a dose-dependent manner with ID50 values of 329 pg kg-1 and 16.6 ng kg-1, respectively. h-nocistatin was about 10 times less potent than b-nocistatin. h-nocistatin also attenuated the nociceptin- and PGE2-induced hyperalgesia. These results demonstrate that h-nocistatin is biologically active and may be involved in the processing of pain at the spinal level in humans. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/sj.bjp.0701995 | |
dc.source | Scopus | |
dc.subject | Allodynia | |
dc.subject | Hyperalgesia | |
dc.subject | Nociceptin/orphanin FQ | |
dc.subject | Prostaglandin E2 | |
dc.subject | Spinal cord | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1038/sj.bjp.0701995 | |
dc.description.sourcetitle | British Journal of Pharmacology | |
dc.description.volume | 124 | |
dc.description.issue | 6 | |
dc.description.page | 1016-1018 | |
dc.description.coden | BJPCB | |
dc.identifier.isiut | 000074965000002 | |
Appears in Collections: | Staff Publications |
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