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Title: Anti-nociceptive responses produced by human putative counterpart of nocistatin
Authors: Minami, T.
Okuda-Ashitaka, E.
Nishiuchi, Y.
Kimura, T.
Tachibana, S. 
Mori, H.
Ito, S.
Keywords: Allodynia
Nociceptin/orphanin FQ
Prostaglandin E2
Spinal cord
Issue Date: 1998
Citation: Minami, T., Okuda-Ashitaka, E., Nishiuchi, Y., Kimura, T., Tachibana, S., Mori, H., Ito, S. (1998). Anti-nociceptive responses produced by human putative counterpart of nocistatin. British Journal of Pharmacology 124 (6) : 1016-1018. ScholarBank@NUS Repository.
Abstract: b-nocistatin is a heptadecapeptide produced from bovine prepronociceptin and blocks the induction of hyperalgesia and touch-evoked pain (allodynia) by intrathecal administration of nociceptin or prostaglandin E2 (PGE2). Human prepronociceptin may generate a 30-amino acid peptide different in length from b-nocistatin. Here, we examine whether the human putative counterpart of nocistatin (h-nocistatin) possessed the same biological activities as b-nocistatin. Simultaneous intrathecal injection of h-nocistatin in mice blocked the induction of allodynia by nociceptin and PGE2 in a dose-dependent manner with ID50 values of 329 pg kg-1 and 16.6 ng kg-1, respectively. h-nocistatin was about 10 times less potent than b-nocistatin. h-nocistatin also attenuated the nociceptin- and PGE2-induced hyperalgesia. These results demonstrate that h-nocistatin is biologically active and may be involved in the processing of pain at the spinal level in humans.
Source Title: British Journal of Pharmacology
ISSN: 00071188
DOI: 10.1038/sj.bjp.0701995
Appears in Collections:Staff Publications

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