Please use this identifier to cite or link to this item:
|Title:||Anti-nociceptive responses produced by human putative counterpart of nocistatin||Authors:||Minami, T.
|Issue Date:||1998||Citation:||Minami, T., Okuda-Ashitaka, E., Nishiuchi, Y., Kimura, T., Tachibana, S., Mori, H., Ito, S. (1998). Anti-nociceptive responses produced by human putative counterpart of nocistatin. British Journal of Pharmacology 124 (6) : 1016-1018. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.bjp.0701995||Abstract:||b-nocistatin is a heptadecapeptide produced from bovine prepronociceptin and blocks the induction of hyperalgesia and touch-evoked pain (allodynia) by intrathecal administration of nociceptin or prostaglandin E2 (PGE2). Human prepronociceptin may generate a 30-amino acid peptide different in length from b-nocistatin. Here, we examine whether the human putative counterpart of nocistatin (h-nocistatin) possessed the same biological activities as b-nocistatin. Simultaneous intrathecal injection of h-nocistatin in mice blocked the induction of allodynia by nociceptin and PGE2 in a dose-dependent manner with ID50 values of 329 pg kg-1 and 16.6 ng kg-1, respectively. h-nocistatin was about 10 times less potent than b-nocistatin. h-nocistatin also attenuated the nociceptin- and PGE2-induced hyperalgesia. These results demonstrate that h-nocistatin is biologically active and may be involved in the processing of pain at the spinal level in humans.||Source Title:||British Journal of Pharmacology||URI:||http://scholarbank.nus.edu.sg/handle/10635/100100||ISSN:||00071188||DOI:||10.1038/sj.bjp.0701995|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 23, 2020
WEB OF SCIENCETM
checked on Jan 14, 2020
checked on Jan 11, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.