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|Title:||AGAMOUS controls GIANT KILLER, a multifunctional chromatin modifier in reproductive organ patterning and differentiation||Authors:||Ng, K.-H.
|Issue Date:||Nov-2009||Citation:||Ng, K.-H., Yu, H., Ito, T. (2009-11). AGAMOUS controls GIANT KILLER, a multifunctional chromatin modifier in reproductive organ patterning and differentiation. PLoS Biology 7 (11) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pbio.1000251||Abstract:||The Arabidopsis homeotic protein AGAMOUS (AG), a MADS domain transcription factor, specifies reproductive organ identity during flower development. Using a binding assay and expression analysis, we identified a direct target of AG, GIANT KILLER (GIK), which fine-tunes the expression of multiple genes downstream of AG. The GIK protein contains an AT-hook DNA binding motif that is widely found in chromosomal proteins and that binds to nuclear matrix attachment regions of DNA elements. Overexpression and loss of function of GIK cause wide-ranging defects in patterning and differentiation of reproductive organs. GIK directly regulates the expression of several key transcriptional regulators, including ETTIN/AUXIN RESPONSE FACTOR 3 (ETT/ARF3) that patterns the gynoecium, by binding to the matrix attachment regions of target promoters. Overexpression of GIK causes a swift and dynamic change in repressive histone modification in the ETT promoter. We propose that GIK acts as a molecular node downstream of the homeotic protein AG, regulating patterning and differentiation of reproductive organs through chromatin organization. © 2009 Ng et al.||Source Title:||PLoS Biology||URI:||http://scholarbank.nus.edu.sg/handle/10635/100019||ISSN:||15449173||DOI:||10.1371/journal.pbio.1000251|
|Appears in Collections:||Staff Publications|
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