Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B
Lu, Y Zheng, Y Liu, X Liang, X Ngai, S Li, T Zhang, W
Zheng, Y
Liu, X
Liang, X
Ngai, S
Li, T
Zhang, W
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Abstract
Background: Radix Salvia miltiorrhiza (Danshen) has been used as a principal herb in treating cardiovascular diseases in Chinese medicine. Salvianolic acid B (SA-B), a water-soluble active component of Danshen, was found to have anti-myocardial ischemia (anti-MI) effect. This study aims to investigate mechanisms of SA-B on MI.Methods: Five conventional Western medicines (isosorbide dinitrate, verapamil, propranolol, captopril and trimethazine) with different mechanisms for treating cardiovascular diseases were selected as positive references to compare with SA-B in changing of the metabolomic profiles in MI rats under treatment. Potential mechanisms of SA-B were further investigated in H9C2 cell line.Results: The metabolomic profiles between SA-B- and propranolol-treated MI rats were similar, since there was a big overlap between the two groups in the PLS-DA score plot. Finally, it was demonstrated that SA-B exhibited a protective effect on MI mainly by decreasing the concentration of cyclic adenosine monophosphate (cAMP) and Ca2+and inhibiting protein kinase A (PKA).Conclusion: SA-B and propanolol exhibited similar metabolomic profiles, indicating that the two drugs might have a similar mechanism. © 2012 Lu et al; licensee BioMed Central Ltd.
Keywords
calcium ion, captopril, cyclic AMP, cyclic AMP dependent protein kinase, isosorbide dinitrate, propranolol, salvianolic acid B, verapamil, animal cell, animal experiment, animal model, article, cardiovascular disease, cell line, controlled study, heart muscle ischemia, male, metabolomics, nonhuman, rat, Salvia miltiorrhiza
Source Title
Chinese Medicine
Publisher
BMC
Series/Report No.
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Rights
Attribution 4.0 International
Date
2012
DOI
10.1186/1749-8546-7-6
Type
Article