Please use this identifier to cite or link to this item: https://doi.org/10.1186/1749-8546-7-6
Title: Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B
Authors: Lu, Y 
Zheng, Y
Liu, X
Liang, X
Ngai, S
Li, T
Zhang, W
Keywords: calcium ion
captopril
cyclic AMP
cyclic AMP dependent protein kinase
isosorbide dinitrate
propranolol
salvianolic acid B
verapamil
animal cell
animal experiment
animal model
article
cardiovascular disease
cell line
controlled study
heart muscle ischemia
male
metabolomics
nonhuman
rat
Salvia miltiorrhiza
Issue Date: 2012
Publisher: BMC
Citation: Lu, Y, Zheng, Y, Liu, X, Liang, X, Ngai, S, Li, T, Zhang, W (2012). Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B. Chinese Medicine 7 : 6. ScholarBank@NUS Repository. https://doi.org/10.1186/1749-8546-7-6
Rights: Attribution 4.0 International
Abstract: Background: Radix Salvia miltiorrhiza (Danshen) has been used as a principal herb in treating cardiovascular diseases in Chinese medicine. Salvianolic acid B (SA-B), a water-soluble active component of Danshen, was found to have anti-myocardial ischemia (anti-MI) effect. This study aims to investigate mechanisms of SA-B on MI.Methods: Five conventional Western medicines (isosorbide dinitrate, verapamil, propranolol, captopril and trimethazine) with different mechanisms for treating cardiovascular diseases were selected as positive references to compare with SA-B in changing of the metabolomic profiles in MI rats under treatment. Potential mechanisms of SA-B were further investigated in H9C2 cell line.Results: The metabolomic profiles between SA-B- and propranolol-treated MI rats were similar, since there was a big overlap between the two groups in the PLS-DA score plot. Finally, it was demonstrated that SA-B exhibited a protective effect on MI mainly by decreasing the concentration of cyclic adenosine monophosphate (cAMP) and Ca2+and inhibiting protein kinase A (PKA).Conclusion: SA-B and propanolol exhibited similar metabolomic profiles, indicating that the two drugs might have a similar mechanism. © 2012 Lu et al; licensee BioMed Central Ltd.
Source Title: Chinese Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/178152
ISSN: 1749-8546
DOI: 10.1186/1749-8546-7-6
Rights: Attribution 4.0 International
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