Metal-Organic Framework as a Simple and General Inert Nanocarrier for Photosensitizers to Implement Activatable Photodynamic Therapy
Hu, Fang MAO DUO KENRY WANG YUXIANG Wu, Wenbo Zhao Dan Kong, Deling LIU BIN
Hu, Fang
Wu, Wenbo
Kong, Deling
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Abstract
There has been a surging interest in the synthesis of activatable photosensitizers (PSs) as they can be selectively activated with minimum nonspecific phototoxic damages for photodynamic therapy (PDT). Conventional strategies to realize activatable PSs are only applicable to a limited number of molecules. Herein, a simple and general strategy to yield activatable PSs by coupling MIL-100 (Fe) (MIL: Materials Institute Lavoisier) with different kinds of PSs is presented. Specifically, when PSs are encapsulated into MIL-100 (Fe), the photosensitization capability is suppressed due to their isolation from O2. After the reaction between iron(III) in MIL-100 (Fe) and H2O2 occurs, the framework of MIL-100 (Fe) collapses and the encapsulated PSs regain contact with O2, leading to activation of photosensitization. In addition, the decomposition of H2O2 can generate O2 to relieve tumor hypoxia and enhance PDT effect. As O2 is an indispensable factor for PDT, the activation strategy should be generally applicable to different PSs for activatable PDT.
Keywords
Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Chemistry, Physical, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Physics, Applied, Physics, Condensed Matter, Chemistry, Science & Technology - Other Topics, Materials Science, Physics, activatable photosensitizers, aggregation-induced emission, hydrogen peroxide, MIL-100 (Fe), oxygen, AGGREGATION-INDUCED EMISSION, DRUG-DELIVERY, CANCER-CELLS, HIGHLY EFFICIENT, SOLID TUMORS, NANOPARTICLES, BIOPROBE, ABLATION, PLATFORM, HYPOXIA
Source Title
Advanced Functional Materials
Publisher
Wiley-VCH Verlag
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Date
2018-05-09
DOI
10.1002/adfm.201707519
Type
Article