Eliana C Martinez Valencia
Email Address
surecmv@nus.edu.sg
Organizational Units
SURGERY
dept
YONG LOO LIN SCH OF MEDICINE
faculty
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Publication Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100(Academic Press, 2015-05-01) Wong, Lee Lee; Wee, Abby S.Y.; Lim, Jia Yuen; Ng, Yan Xia, Jessica; Chong, Jenny P.C.; Lew, Oi Wah; LILYANNA SHERA; Valencia, Eliana C. Martinez; Ackers-Johnson, Matthew Andrew; Vardy, Leah A.; Arunmozhiarasi, Armugam; Kandiah, Jeyaseelan; Ng, Tze Pin; Lam, Su Ping, Carolyn; Foo, Roger S.Y.; Richards, Arthur Mark; Chen, Yei-Tsung; MEDICINE; SURGERY; PSYCHOLOGICAL MEDICINE; BIOCHEMISTRYPublication Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction(ELSEVIER SCIENCE INC, 2018-04-01) de Carvalho, Leonardo P; Tan, Sock Hwee; Ow, Ghim-Siong; Tang, Zhiqun; Ching, Jianhong; Kovalik, Jean-Paul; Poh, Sock Cheng; Chin, Chee-Tang; Richards, A Mark; Martinez, Eliana C; Troughton, Richard W; Fong, Alan Yean-Yip; Yan, Bryan P; Seneviratna, Aruni; Sorokin, Vitaly; Summers, Scott A; Kuznetsov, Vladimir A; Chan, Mark Y; Assoc Prof Yan Yee Mark Chan; MEDICINE; SURGERY; DUKE-NUS MEDICAL SCHOOLWe identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.Publication Incorporation of a prolyl hydroxylase inhibitor into scaffolds: A strategy for stimulating vascularization(Mary Ann Liebert, 2015-03-09) Sham, Adeline; Valencia, Eliana C. Martinez; Beyer, Sebastian; Trau, Dieter Wilhelm; Raghunath, Michael; SURGERY; DIVISION OF BIOENGINEERINGPublication Myocardial tissue engineering: The quest for the ideal myocardial substitute(2009) Martinez, E.C.; Kofidis, T.; SURGERYPublication Determinants of Bioartificial Myocardial Graft Survival and Engraftment In Vivo(2008) Mueller-Stahl, K.; Kofidis, T.; Akhyari, P.; Lenz, A.; Haverich, A.; Lee, D.H.L.; Martinez, E.C.; Woitek, F.; SURGERYBackground: The specific interactions between tissue-engineered grafts and host tissue are frequently neglected. The aim of this study was to describe and quantify the fate of a tissue-engineered cardiac graft in vivo. Methods: Neonatal rat cardiomyocytes were cast into a collagen mesh, forming a bioartificial myocardial tissue (AMT). After 7 days in vitro, four groups were formed (Group A: sham; Group B: matrix; Group C: AMT [with additional host treatment with cyclosporine and prednisolone]; Group D: AMT; each n = 5) and the tissue grafts were implanted into the muscle pouch of adult rats at 14, 21 and 28 days. Implants were stained for troponin-T, BrdU, MF-20, desmin, vimentin, Flk-1, CD8, CD4, pentachrome, PSR and H&E. Results: AMT cell count, cell proportion, contractility, viability and metabolism proved stable in vitro. Grafted cells decreased over time and were detected in Group C until the end of the experiment (Day 28), and in Group D until Day 21. Angiogenesis began at the peripheries and slowly progressed toward the cores of the grafts. The thickness and collagen content of the matrix remained stable in Group C for 14 days, and decreased in all groups until Day 28 (thickness: Group B, -66%; Group C, -50%; Group D, -100%). Grafts were predominately infiltrated by macrophages and stromal cells, and less so by lymphocytes (Group D > B > C). Conclusion: The differentiation of cardiac and non-cardiac grafted cells, infiltrating cells, scaffold kinetics and angiogenesis showed host immune responses and degree of angiogenesis to be the determinants for AMT graft survival. © 2008 International Society for Heart and Lung Transplantation.Publication Off-pump coronary bypass grafting is safe and efficient in patients with left main disease and higher EuroScore(2009) Thomas, G.N.; Sakaguchi, H.; Muecke, S.; Lee, C.N.; Kofidis, T.; Martinez, E.C.; Woitek, F.; Emmert, M.Y.; SURGERYBackground: Summary Left main disease (LMD) and associated cardiac risk factors are often perceived as a limiting factor for the outcome of off-pump coronary artery bypass (OPCAB) grafting. In this study, we assess whether the outcome of OPCAB surgery is affected in such patients. Methods: We retrospectively compared perioperative parameters in 66 OPCAB patients (group A) with LMD and 216 OPCAB patients without (group B) LMD. The patients were operated in the time frame between 2002 and 2007. LMD was defined as a stenosis >50%. Results: Patients in group A had a higher EuroSCORE (logistic: 3.7 ± 0.1 vs 6.3 ± 0.3, p = 0.027), increased coronary artery disease (CAD) family history (p = 0.015) and cerebrovascular accidents (p = 0.027), increased history of congestive heart failure (p = 0.013), more urgent surgery (p = 0.008), previous percutaneous transluminal coronary angioplasties (PTCAs) (p = 0.05) and previous stent implantation (p = 0.023). An intra-aortic balloon pump (IABP) was inserted more frequently in the LMD group preoperatively (p = 0.004). There were two conversions to on-pump during OPCAB surgery. There were no differences in the postoperative outcomes in the LMD group A versus group B, such as cardiac-related events, neurological deficits, cardiac enzyme course, arrhythmias, blood loss, infections and renal failure. Conclusions: The presence of LMD and higher EuroSCORE does not yield adverse outcomes in OPCAB patients. © 2009 European Association for Cardio-Thoracic Surgery.Publication Consequences of incomplete repair of acute type A aortic dissection(2008) Sorokin, V.A.; Kofidis, T.; Woitek, F.; Martinez, E.C.; Chuen, N.L.; Klima, U.; SURGERYPublication First paediatric left ventricular assist device implantation as bridge-to-recovery in Singapore(2009) Kofidis, T.; Klima, U.; Chuen, N.L.; Woitek, F.; Swee, C.Q.; Bee, L.A.; Martinez, E.C.; SURGERY; PAEDIATRICSPublication Off-pump versus on-pump coronary artery bypass procedures: Postoperative renal complications in an asian population(2010) Loganathan, S.; Nieh, C.C.; Emmert, M.Y.; Woitek, F.; Martinez, E.C.; Muecke, S.; Lee, C.N.; Kofidis, T.; SURGERYPublication Off-pump coronary bypass surgery is safe in patients with a low ejection fraction (≤25%)(2010) Emmert, M.Y.; Emmert, L.S.; Martinez, E.C.; Lee, C.N.; Kofidis, T.; SURGERY