Lee, How Sung
Email Address
phcleehs@nus.edu.sg
Organizational Units
PHARMACOLOGY
dept
YONG LOO LIN SCH OF MEDICINE
faculty
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Publication Population pharmacokinetics of phenytoin in Singapore Chinese(1990) Chan, E.; Ti, T.Y.; Lee, H.S.; PHARMACOLOGYPublication Population pharmacokinetics of carbamazepine in Singapore epileptic patients(2001) Chan, E.; Lee, H.S.; Hue, S.S.; PHARMACOLOGY; PHARMACYPublication Phenotyping CYP3A using midazolam in cancer and noncancer Asian patients(2003) Lee, H.S.; Fan, L.; Khoo, Y.M.; Goh, B.C.; Wang, L.; Lim, R.; Ong, A.B.; Chua, C.; PHARMACOLOGYPublication Absorption of mercuric sulphide following oral administration in mice(1986) Yeoh, T.S.; Lee, A.S.; Lee, H.S.; PHARMACOLOGYPublication Serum and urine risperidone concentrations in an acute overdose [4](1997) Lee, H.S.; Tan, C.H.; Au, L.S.Y.; Khoo, Y.M.; PHARMACOLOGYPublication Gastrointestinal absorption of mercury following oral administration of cinnabar in a traditional Chinese medicine(1989) Yeoh, T.S.; Lee, H.S.; Lee, A.S.; PHARMACOLOGYPublication Ganglion blocking activity of cimetidine in the anaesthetized cat(1985) Gwee, M.C.E.; Cheah, L.S.; Lee, H.S.; PHARMACOLOGYPublication A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma(2009) Wang, M.; ZHOU JIN; Casey, P.; Khoo, Y.M.; Lee, H.S.; PHARMACOLOGYCysmethynil, a newly identified small molecule inhibitor of isoprenylcysteine carboxylmethyl transferase (Icmt) is involved in the post-translational modification of CaaX proteins. Cysmethynil causes cell death in many human cancer cells in vitro, and inhibits tumor growth in the xenograft mouse model in vivo. A HPLC method for the quantification of cysmethynil in mouse plasma was developed and validated. The lower limit of quantification of this method was 0.01 μg/ml. Inter- and intra-day variability ranged from 0.38-8.5% and accuracy was between 86% and 98%. This sensitive method was used to quantify cysmethynil in plasma of mice after intraperitoneal dosing for preliminary pharmacokinetic studies. © 2009 Elsevier B.V. All rights reserved.Publication A case report of occupational asthma due to gluteraldehyde exposure(2004-03) Ong, TH; Tan, KL; Lee, HS; Eng, P; Assoc Prof Lee Hock Siang; PHARMACOLOGY; MEDICINEIntroduction: We report the first case of occupational asthma due to gluteraldehyde exposure in Singapore and also describe the use of a specific inhalational challenge (SIC) test in confirming the diagnosis. Clinical Picture: A 32-year-old laboratory technician presented with adult-onset asthma 2 years after daily exposure to gluteraldehyde which was used to sterilise the mouthpieces used for lung function testing. SIC testing showed a 25% drop in FEV1 after exposure to gluteraldehyde but not after exposure to a control, thus confirming the diagnosis. Treatment: Alternative arrangements were made for sterilisation of the mouthpieces so that gluteraldehyde could be removed from the workplace. There was a marked improvement in her asthmatic control thereafter. Conclusions: This case illustrates the use of a SIC test in the diagnosis of occupational asthma. Gluteraldehyde is a known cause of occupational asthma and should be kept in mind when evaluating asthmatic patients in at-risk occupations. Effective ventilation and proper storage should be ensured to minimise exposure to gluteraldehyde where its use is necessary.Publication Effects of mefloquine on Ca2+ uptake and release by dog brain microsomes(1996) Lee, H.S.; Go, M.L.; PHARMACOLOGY; PHARMACYThe effects of the antimalarial drug, mefloquine, on the uptake and release of Ca2+ by crude microsomes from dog brain were investigated using a spectrophotometric method. Mefloquine inhibited the inositol-1,4,5-phosphate (IP3)-induced Ca2+ release with an IC50 of 42 μM, but was a weaker inhibitor of the uptake of Ca2+ into the vesicles (IC50: 272 μM). These effects of mefloquine are in contrast to its actions on Ca2+ uptake and release by skeletal muscle microsomes, where its predominant effect was seen to be the inhibition of Ca2+ uptake into the vesicles. Mefloquine was found to be more potent than quinine as a specific inhibitor of Ca2+ release from IP3-sensitive stores in dog brain microsomes. The possibility of the drug affecting cellular IP3-linked signal transduction processes should be considered.