Yong Sheng Chng

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chmcys@nus.edu.sg


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    Protecting-Group-Free Synthesis of Chondroitin 6-Sulfate Disaccharide and Tetrasaccharide
    (AMER CHEMICAL SOC, 2019-06-21) Chng, Yong Sheng; Tristan, Geordi; Yip, George W; Lam, Yulin; Assoc Prof Yulin Lam; ANATOMY; CHEMISTRY; CHEMICAL & BIOMOLECULAR ENGINEERING
    Chondroitin 6-sulfate (CS-C) is an important glycosaminoglycan that regulates many physiological functions including the development, progression, and metastasis of cancer. To understand its mechanism of action at the molecular level, CS-C molecules of defined length are required. A protecting group-free synthesis of CS-C disaccharide and tetrasaccharide from the CS-A polymer that involves only three steps and furnishes CS-O disaccharide and tetrasaccharide as intermediates is reported.