Nilmani Saha
Email Address
paens@nus.edu.sg
Organizational Units
YONG LOO LIN SCH OF MEDICINE
faculty
PAEDIATRICS
dept
88 results
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Publication Acute phase proteins in male Chinese schizophrenic patients in Singapore(1996) Wong, C.-T.; Tsoi, W.-F.; Saha, N.; PHYSIOLOGY; PSYCHOLOGICAL MEDICINE; PAEDIATRICSChanges in the concentration of some serum acute phase proteins (α1-antitrypsin, α2-macroglobulin, complement C3, haptoglobin, ceruloplasmin, transferrin, albumin and hemopexin), thyroxine-binding globulin, retinol-binding globulin, plasminogen and Gc-globulin are reported in two separate series of Chinese, male schizophrenic patients and healthy controls. In the first series, 41 healthy blood donors and 98 schizophrenic patients in different stages of the disease were investigated. The second series consists of a random sample of 50 acutely ill schizophrenic patients and a second group of healthy subjects. The concentrations of these serum proteins were measured by rocket immunoelectrophoresis in agarose gel. Increased levels of serum α1-antitrypsin, α2-macroglobulin, haptoglobin, ceruloplasmin, and thyroxine-binding globulin were observed in both series of patients when compared to their respective controls. Albumin, transferrin and retinol-binding protein levels were reduced in patients in both series. Hemopexin levels were increased only in the acutely ill patients while complement C3 was decreased in the chronically ill patients. No changes were observed in the Gc-globulin levels of all groups of patients. With the exception of complement C3, the changes observed in the levels of these serum proteins were appropriate for that of an acute phase response.Publication Ethnic differences in interferon-α allele frequencies(1997) Golovleva, I.; Beckman, L.; Saha, N.; PAEDIATRICSPublication Lack of association of the dopamine D3 receptor gene polymorphism (BalI) in Chinese schizophrenic males(1994) Saha, N.; Tsoi, W.F.; Low, P.S.; Basair, J.; Tay, J.S.H.; PAEDIATRICSPublication Restriction fragment length polymorphism (RFLP) at the DNF15S2 locus in three ethnic groups of Singapore(1990) Saha, N.; Tay, J.S.H.; Carritt, B.; PAEDIATRICSPublication DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore(1993) Saha, N.; Tay, J.S.H.; Heng, C.K.; Humphries, S.E.; PAEDIATRICSPublication Genotype associations among seven apolipoprotein B polymorphisms in a population of Orang Asli of western Malaysia(1997) Gajra, B.; Candlish, J.K.; Heng, C.K.; Saha, N.; Mak, J.W.; PAEDIATRICS; BIOCHEMISTRYPublication Xg(a) blood group in Chinese, Malays and Indians in Singapore(1973) Saha, N.; Banerjee, B.; PHYSIOLOGY101 Chinese, 72 Malays and 91 south Indians, resident in Singapore, were investigated for the distribution of the Xg(a) blood group. The Xg(a) gene frequencies for Chinese, Malay and Indian subjects were 0.45, 0.54 and 0.57, respectively.Publication Origin of the Koreans: A population genetic study(1992) Saha, N.; Tay, J.S.H.; PAEDIATRICSPublication DNA polymorphisms of the apolipoprotein B gene in Chinese coronary artery disease patients(1992) Saha, N.; Tong, M.C.; Tay, J.S.H.; Jeyaseelan, K.; Humphries, S.E.; PAEDIATRICS; BIOCHEMISTRYPublication Racial variation of factor VII activity and antigen levels and their correlates in healthy Chinese and Indians at low and high risk for coronary artery disease(1995) Saha, N.; Heng, C.K.; Mozoomdar, B.P.; Reuben, E.M.; Soh, H.T.; Low, P.S.; Tay, J.S.H.; Liu, Y.; Hong, S.; PAEDIATRICSPlasma factor VII activity (FVIIc) is one of the independent risk factors of coronary artery disease (CAD) and is controlled by both genetic and environmental factors. South Asians including Indians have one of the highest prevalence and mortality rates from CAD while the Chinese have a much lower risk. Generally accepted risk factors cannot explain the high mortality from CAD in Indians. We examined two hundred and seventy seven Chinese (124 m, 153 f); and 216 healthy Indian (150 m, 66 f) adults for serum lipids; plasma FVIIc and FVIIag levels in order to examine racial variations of these and their correlates in these two populations. Both Indian men and women had significantly higher FVIIc levels (12% and 11%, respectively) than the Chinese even after adjustments of age, BMI and lipids (P < 0.01). In contrast, Indians had significantly lower plasma FVIIag levels than Chinese (8% and 9%, respectively in men and women; P < 0.01). Multiple linear regression analysis shows a strong correlation of FVIIc with serum triglycerides accounting for 4-8% of the total variability of FVIIc in different groups. Further, there was a stronger correlation between FVIIc and FVIIag in Indians than that in the Chinese (0.43 vs. 25) suggesting a greater activation resulting in higher FVIIc in Indians inspite of lower FVIIag levels. The higher FVIIc and stronger activation by triglycerides observed in this study partly explain the higher risk of CAD in Indians.