Wilder-Smith, Einar P V
Email Address
mdcwse@nus.edu.sg
Organizational Units
MEDICINE
dept
YONG LOO LIN SCH OF MEDICINE
faculty
106 results
Publication Search Results
Now showing 1 - 10 of 106
Publication Water-immersion wrinkling is due to vasoconstriction(2003) Wilder-Smith, E.P.V.; Chow, A.; MEDICINEPublication Relationship of inspiratory flow rate and volume on digit tip skin and ulnar artery vasoconstrictor responses in healthy adults(2005) Wilder-Smith, E.; Liu, L.; Ma, K.T.M.; Ong, B.K.C.; MEDICINEReflex vasoconstrictive responses are commonly used to assess sympathetic nerve function of the extremities. A regularly used reflex trigger is deep and rapid inspiration. However, little is known about the relationship between respiratory effort and the magnitude of the resultant vasoconstrictor response. This study investigates the association of inspiratory flow rate and volume to the level of vasoconstrictor reflexes in the 4th digit tip skin and the ulnar artery in 12 healthy volunteers (age range 21-65, mean 38.1 years). The effects of Peak Inspiratory Flow (PIF) and Forced Inspiratory Vital Capacity (FIVC) on blood flow were measured at three levels of respiratory effort: low (PIF < 1.0 l/min; FIVC < 1.0 l), medium (PIF = 1.0-1.5 l/min; FIVC = 1.0-1.5 l), and high (PIF > 1.5 l/min; FIVC > 1.5 l) at two separate occasions. Ulnar vasoconstrictor responses showed good correlation with all levels of respiratory effort. Skin digit tip responses showed good correlation at medium and high levels but not at low respiratory effort. Repeatability of both tests was good. Correlation of inspiratory flow rate to vasoconstriction was consistently better than with inspiratory volume. Both digit tip and ulnar vasoconstrictor responses were maximal with greatest respiratory effort. © 2005 Elsevier Inc. All rights reserved.Publication A novel methodology to probe endothelial differential gene expression profile reveals ovel genes(2007) Shen, Y.; Yu, E.; Wong, M.C.; Spence, I.; Wilder-Smith, E.; Ng, Y.K.; Ling, E.A.; MEDICINE; ANATOMYPublication Pool players' headache(2005) Lim, E.C.-H.; Ong, B.K.C.; Wilder-Smith, E.P.V.; MEDICINEPublication Generalised myoclonus evolving into epilepsia partialis continua due to a cingulate gyrus lesion: Case report and review of the literature(2004-10) Lim, E.C.H.; Tan, J.J.H.; Ong, B.K.C.; Wilder-Smith, E.P.V.; MEDICINEA young Chinese male was admitted for a generalised tonic-clonic seizure preceded by a week-long history of fever. Subsequently, he developed continuous myoclonic jerks in all four limbs, with clear left sided predominance, and no accompanying clouding of consciousness. Contrast MRI of the brain demonstrated a venous angioma in the right cingulate gyrus. Over the next few days, the clinical picture evolved, with focal motor status involving primarily the left lower limb and the abdomen. These movements resolved with anticonvulsant therapy. This case illustrates generalised myoclonus arising from a focal brain abnormality. The epileptiform aetiology became obvious only after evolution into the typical features of a focal motor seizure and supportive neuroimaging. This demonstrates the protean manifestations of epileptic seizures which have been ascribed to the cingulate gyrus. The lack of clear declarative clinical and EEG features highlights the melding of the fields of epileptology and movement disorders. © 2004 Elsevier Ltd. All rights reserved.Publication Effect of hand position on digit and ulnar artery vasoconstrictor reflexes(2005) Wilder-Smith, E.P.; Liurong, L.; Guo, Y.; MEDICINEPublication Erratum: The INFIR cohort study: Investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary leprosy patients in North India (Leprosy Review (March))(2005) Van, Brakel W.H.; Nicholls, P.G.; Das, L.; Barkataki, P.; Suneetha, S.K.; Jadhav, R.S.; Maddali, P.; Lockwood, D.N.J.; Wilder-Smith, E.; Desikan, K.V.; MEDICINEPublication Symptoms associated with electrophysiologically verified carpal tunnel syndrome in asian patients(2006) Wilder-Smith, E.P.; Lirong, L.; Seet, R.C.S.; Lim, E.C.H.; MEDICINESensory symptoms are crucial for the diagnosis of carpal tunnel syndrome (CTS). We have studied the spectrum of sensory symptoms in 67 cases of neurophysiologically confirmed CTS in Singapore and investigated the correlation of semi-quantitative clinical ('Historical-Objective') and neurophysiological ('Bland') scales. The range of sensory symptoms was large. The more frequent use of the terms 'woodenness' and 'aching' rather than 'pins and needles' suggests racial and cultural differences in symptom expression, or recognition of previously ignored descriptors. 'Numbness' (97%) was the most common descriptive symptom, followed by 'tingling' (81%), 'tightness' (60%), 'aching' (45%), 'woodenness' (39%) and 'pins and needles' (33%). Less common were 'deadness' (27%), prickling (24%), and cramp-like pain (18%). Uncommon sensations included 'jabbing' (10%), 'shooting pain' (10%), 'stabbing' (9%), 'tight-band like pressure' (9%), 'cold' (8%), 'crushing' (6%) and 'burning' (6%). The semi-quantitative clinical and neurophysiological scales correlated well (Pearson 0.645, P<0.001). © 2006 The British Society for Surgery of the Hand.Publication Variability of the palmar cutaneous branch median nerve sensory nerve action potential with carpal tunnel syndrome [6](2007) Wilder-Smith, E.; Kannan, A.; MEDICINEPublication MRI in non-alcoholic Wernicke's encephalopathy(2008-04) Rathakrishnan, R.; Smith, E.-W.; MEDICINE