Zhe Shen

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medszi@nus.edu.sg


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    Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore
    (BioMed Central Ltd., 2017-10-18) Padmapriya N.; Bernard J.Y.; Liang S.; Loy S.L.; Cai S.; Zhe I.S.; Kwek K.; Godfrey K.M.; Gluckman P.D.; Saw S.M.; Chong Y.-S.; Chan J.K.Y.; MUELLER-RIEMENSCHNEIDER FALK; Sheppard A.; Chinnadurai A.; Neo Goh A.E.; Rifkin-Graboi A.; Qiu A.; Biswas A.; Lee B.W.; Broekman B.F.P.; Quah B.L.; Shuter B.; Chng C.K.; Ngo C.; Bong C.L.; Henry C.J.; Ing Chee C.Y.; Daniel Goh Y.T.; Fok D.; Yap F.; Heong Yeo G.S.; Chen H.; van Bever H.P.S.; Magiati I.; Yun Wong I.B.; Lau I.Y.-M.; Kapur J.; Richmond J.L.; Holbrook J.D.; Gooley J.J.; Tan K.H.; Niduvaje K.; Singh L.; Su L.L.; Daniel L.M.; Shek L.P.-C.; Fortier M.V.; Hanson M.; MARY CHONG FOONG FONG; Rauff M.; Chua M.C.; Meaney M.; Tint M.T.; Karnani N.; Lek N.; Teoh O.H.; Wong P.C.; Agarwal P.; van Dam R.M.; Rebello S.A.; Chong S.C.; Soh S.-E.; Lim S.B.; Hsu C.-Y.S.; Rajadurai V.S.; Stunkel W.; Han W.M.; Pang W.W.; CHEUNG YIN BUN; Chan Y.H.; Lee Y.S.; DEAN'S OFFICE (MEDICINE); BIOMEDICAL ENGINEERING; SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH; DUKE-NUS MEDICAL SCHOOL; OBSTETRICS & GYNAECOLOGY
    Background: Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women. Methods: As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26-28 weeks' gestation we measured FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L). Associations were analysed by multiple linear and logistic regression. Results: Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG, 2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a lower likelihood of GDM (p-trend < 0.05), but not with FG levels. Compared to insufficiently active women, highly active women had lower 2hPG levels [β (95% CI): -0.32 (-0.59, -0.05), p = 0.020) and were less likely to have GDM [OR: 0.56 (0.32-0.98), p = 0.040]. Stratified analysis revealed no associations among under/normal-weight women, but significant associations among overweight/obese women; in those with BMI ≥23 kg/m2, sufficiently active and highly active women were less likely to have GDM [OR: 0.52, (0.29-0.93), p = 0.028, and OR: 0.34, (0.15-0.77), p = 0.010, respectively]. Conclusion: Higher PA was associated with lower 2hPG levels and a lower prevalence of GDM, particularly in overweight/obese women. Further studies are warranted to confirm these findings, and to examine the effectiveness of PA promotion strategies for the prevention of gestational hyperglycemia. © 2017 The Author(s).
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    Publication
    Association of physical activity and sedentary behavior with depression and anxiety symptoms during pregnancy in a multiethnic cohort of Asian women
    (Springer Verlag, 2016-12-01) NATARAJAN PADMAPRIYA; Bernard, J. Y.; Liang, S.; Loy, S. L.; Shen, Z.; Kwek, K.; Godfrey, K. M.; Gluckman, P. D.; Chong, Y. S.; Saw, S. M.; Meaney, M. J.; Chen, H.; Muller-Riemenschneider, F.; DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE; SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH; OBSTETRICS & GYNAECOLOGY
    Objectives: This study aimed to investigate associations of physical activity (PA) and sedentary behavior (SB) with depression and anxiety symptoms during pregnancy among Chinese, Malay, and Indian women. Methods: Women answered PA and SB (sitting time and television time) interview questions and self-completed the Edinburgh Postnatal Depression Scale (EPDS) and State-Trait Anxiety Inventory (STAI) questionnaires, at week 26–28 gestation. Sufficient levels of PA (≥600MET-minutes/week) and higher sitting time (≥7 h/day) were determined. Associations of PA and SB with probable antenatal depression (EPDS-score ≥15), higher state anxiety (score ≥42), and higher trait anxiety (score ≥43) were determined by logistic regression analysis. Results: Among the 1144 pregnant women included in the study, 7.3, 22.5, and 23.6 % had probable antenatal depression, higher state anxiety, and higher trait anxiety symptoms, respectively. In the adjusted models, women with sufficient level of PA were less likely to have probable antenatal depression (OR 0.54, 95 % CI 0.31–0.94, p = 0.030) and higher trait anxiety symptoms (OR 0.68, 95 % CI 0.48–0.94, p = 0.022). PA was not associated with state anxiety symptoms. SB was not associated with any of the investigated outcomes. Conclusions: Sufficient PA was associated with a reduced likelihood of probable antenatal depression and trait anxiety symptoms. Further investigation of these findings is warranted to determine cause-effect relationships and identify potential preventive strategies. © 2016, Springer-Verlag Wien.