Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201106672
Title: Versatile enantioselective [3+2] cyclization between imines and allenoates catalyzed by dipeptide-based phosphines
Authors: Han, X.
Zhong, F.
Wang, Y.
Lu, Y. 
Keywords: allenes
cycloadditions
heterocycles
nucleophilic catalysis
phosphines
Issue Date: 16-Jan-2012
Source: Han, X., Zhong, F., Wang, Y., Lu, Y. (2012-01-16). Versatile enantioselective [3+2] cyclization between imines and allenoates catalyzed by dipeptide-based phosphines. Angewandte Chemie - International Edition 51 (3) : 767-770. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201106672
Abstract: A fast one: The title reaction proceeds in the presence of 5 mol % of the catalyst 1, and is complete within an hour. The 2-alkyl- and 2-aryl-substituted 3-pyrroline products are obtained in good yield and with high enantioselectivity. The application of the method to the concise formal synthesis of (+)-trachelanthamidine is also demonstrated. Boc=tert- butoxycarbonyl, M.S.=molecular sieves, TBDPS=tert-butyldiphenylsilyl. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/77350
ISSN: 14337851
DOI: 10.1002/anie.201106672
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