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https://doi.org/10.1002/anie.201106672
| Title: | Versatile enantioselective [3+2] cyclization between imines and allenoates catalyzed by dipeptide-based phosphines | Authors: | Han, X. Zhong, F. Wang, Y. Lu, Y. |
Keywords: | allenes cycloadditions heterocycles nucleophilic catalysis phosphines |
Issue Date: | 16-Jan-2012 | Citation: | Han, X., Zhong, F., Wang, Y., Lu, Y. (2012-01-16). Versatile enantioselective [3+2] cyclization between imines and allenoates catalyzed by dipeptide-based phosphines. Angewandte Chemie - International Edition 51 (3) : 767-770. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201106672 | Abstract: | A fast one: The title reaction proceeds in the presence of 5 mol % of the catalyst 1, and is complete within an hour. The 2-alkyl- and 2-aryl-substituted 3-pyrroline products are obtained in good yield and with high enantioselectivity. The application of the method to the concise formal synthesis of (+)-trachelanthamidine is also demonstrated. Boc=tert- butoxycarbonyl, M.S.=molecular sieves, TBDPS=tert-butyldiphenylsilyl. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/77350 | ISSN: | 14337851 | DOI: | 10.1002/anie.201106672 |
| Appears in Collections: | Staff Publications |
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