Please use this identifier to cite or link to this item: https://doi.org/10.1002/1097-4636(200101)54:1<59
Title: Preparation and characterization of chitin beads as a wound dressing precursor
Authors: Muhammad Yusof, N.L.B.
Lim, L.Y. 
Khor, E. 
Keywords: Carboxymethyl chitin
Chitin
Chitin beads
Cytotoxicity
Water uptake
Issue Date: Jan-2001
Source: Muhammad Yusof, N.L.B.,Lim, L.Y.,Khor, E. (2001-01). Preparation and characterization of chitin beads as a wound dressing precursor. Journal of Biomedical Materials Research 54 (1) : 59-68. ScholarBank@NUS Repository. https://doi.org/10.1002/1097-4636(200101)54:1<59
Abstract: Chitin was dissolved in N, N-dimethylacetamide/5% lithium chloride (DMAc/5%LiCl) to form a 0.5% chitin solution. Chitin beads were formed by dropping the 0.5% chitin solution into a nonsolvent coagulant, ethanol. The beads were left in ethanol for 24 h to permit hardening, consolidation, and removal of residual DMAc/5%LiCl solvent in order to give spherical chitin beads uniform size distribution. The ethanol-gelled chitin beads had an average diameter of 535 μm. The chitin beads were subsequently activated in 50% (w/v) NaOH solution and reacted with 1.9 M monochloroacetic acid/2-propanol solution to introduce a carboxymethylated surface layer to the chitin beads. The bilayer character of the surface-carboxymethylated chitin (SCM-chitin) beads was verified by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and confocal microscopy. The bilayered SCM-chitin beads were found to absorb up to 95 times their dry weight of water. These SCM-chitin beads have potential as a component of wound dressings. (C) 2000 John Wiley and Sons, Inc.
Source Title: Journal of Biomedical Materials Research
URI: http://scholarbank.nus.edu.sg/handle/10635/76804
ISSN: 00219304
DOI: 10.1002/1097-4636(200101)54:1<59
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