Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.clinthera.2012.06.025
Title: Prevalence of the Coprescription of Clinically Important Interacting Drug Combinations Involving Oral Anticancer Agents in Singapore: A Retrospective Database Study
Authors: Ko, Y. 
Tan, S.L.D.
Chan, A. 
Wong, Y.-P.
Yong, W.-P. 
Ng, R.C.H.
Lim, S.-W. 
Salim, A. 
Keywords: Cancer
Drug interactions
Oral anticancer agents
Prescriptions
Prevalence
Issue Date: Aug-2012
Source: Ko, Y., Tan, S.L.D., Chan, A., Wong, Y.-P., Yong, W.-P., Ng, R.C.H., Lim, S.-W., Salim, A. (2012-08). Prevalence of the Coprescription of Clinically Important Interacting Drug Combinations Involving Oral Anticancer Agents in Singapore: A Retrospective Database Study. Clinical Therapeutics 34 (8) : 1696-1704. ScholarBank@NUS Repository. https://doi.org/10.1016/j.clinthera.2012.06.025
Abstract: Background: There has been a recent increase in the availability and use of oral anticancer agents (OAAs). Drug-drug interactions (DDIs) involving OAAs pose a major concern in oncology practice due to these drugs' narrow therapeutic indices and potential for compromised efficacy and fatal adverse events. Objective: To assess the prevalence of the coprescription of potentially interacting drug combinations involving OAAs in Singapore. Methods: A retrospective review of physicians' electronic prescription records between the years 2007 and 2009 was performed in the largest cancer center in Singapore. An overall prevalence rate of potential DDIs and a prevalence rate for each individual DDI pair were calculated. Logistic regression was used to identify risk factors for potential DDIs. Results: Fifty-eight clinically significant DDIs were selected for evaluation from Drug Interaction Facts and Micromedex DrugDex. A total of 39,772 OAA prescriptions prescribed to 8837 patients were reviewed. Potential DDI coprescription was found in 5.4% of the patients on OAAs and in 4.7% of the OAA prescriptions. The drug pair prescribed to the largest number of patients was prednisolone and aspirin. About half (53.3%) of the observed DDIs were found on the same prescription. On multivariate analysis, older patients, males, and those taking prednisolone had a higher risk for potential DDIs. Conclusion: Although limited by the data available, the analysis of prescription records found that ~5% of patients taking OAAs in Singapore were exposed to ≥1 potentially interacting drug combination. © 2012 Elsevier HS Journals, Inc.
Source Title: Clinical Therapeutics
URI: http://scholarbank.nus.edu.sg/handle/10635/53107
ISSN: 01492918
DOI: 10.1016/j.clinthera.2012.06.025
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