Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.clinthera.2012.06.025
DC Field | Value | |
---|---|---|
dc.title | Prevalence of the Coprescription of Clinically Important Interacting Drug Combinations Involving Oral Anticancer Agents in Singapore: A Retrospective Database Study | |
dc.contributor.author | Ko, Y. | |
dc.contributor.author | Tan, S.L.D. | |
dc.contributor.author | Chan, A. | |
dc.contributor.author | Wong, Y.-P. | |
dc.contributor.author | Yong, W.-P. | |
dc.contributor.author | Ng, R.C.H. | |
dc.contributor.author | Lim, S.-W. | |
dc.contributor.author | Salim, A. | |
dc.date.accessioned | 2014-05-19T02:54:20Z | |
dc.date.available | 2014-05-19T02:54:20Z | |
dc.date.issued | 2012-08 | |
dc.identifier.citation | Ko, Y., Tan, S.L.D., Chan, A., Wong, Y.-P., Yong, W.-P., Ng, R.C.H., Lim, S.-W., Salim, A. (2012-08). Prevalence of the Coprescription of Clinically Important Interacting Drug Combinations Involving Oral Anticancer Agents in Singapore: A Retrospective Database Study. Clinical Therapeutics 34 (8) : 1696-1704. ScholarBank@NUS Repository. https://doi.org/10.1016/j.clinthera.2012.06.025 | |
dc.identifier.issn | 01492918 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/53107 | |
dc.description.abstract | Background: There has been a recent increase in the availability and use of oral anticancer agents (OAAs). Drug-drug interactions (DDIs) involving OAAs pose a major concern in oncology practice due to these drugs' narrow therapeutic indices and potential for compromised efficacy and fatal adverse events. Objective: To assess the prevalence of the coprescription of potentially interacting drug combinations involving OAAs in Singapore. Methods: A retrospective review of physicians' electronic prescription records between the years 2007 and 2009 was performed in the largest cancer center in Singapore. An overall prevalence rate of potential DDIs and a prevalence rate for each individual DDI pair were calculated. Logistic regression was used to identify risk factors for potential DDIs. Results: Fifty-eight clinically significant DDIs were selected for evaluation from Drug Interaction Facts and Micromedex DrugDex. A total of 39,772 OAA prescriptions prescribed to 8837 patients were reviewed. Potential DDI coprescription was found in 5.4% of the patients on OAAs and in 4.7% of the OAA prescriptions. The drug pair prescribed to the largest number of patients was prednisolone and aspirin. About half (53.3%) of the observed DDIs were found on the same prescription. On multivariate analysis, older patients, males, and those taking prednisolone had a higher risk for potential DDIs. Conclusion: Although limited by the data available, the analysis of prescription records found that ~5% of patients taking OAAs in Singapore were exposed to ≥1 potentially interacting drug combination. © 2012 Elsevier HS Journals, Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.clinthera.2012.06.025 | |
dc.source | Scopus | |
dc.subject | Cancer | |
dc.subject | Drug interactions | |
dc.subject | Oral anticancer agents | |
dc.subject | Prescriptions | |
dc.subject | Prevalence | |
dc.type | Article | |
dc.contributor.department | PHARMACY | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1016/j.clinthera.2012.06.025 | |
dc.description.sourcetitle | Clinical Therapeutics | |
dc.description.volume | 34 | |
dc.description.issue | 8 | |
dc.description.page | 1696-1704 | |
dc.description.coden | CLTHD | |
dc.identifier.isiut | 000307794400005 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.