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| Title: | Optimization of the reversed-phase high-performance, liquid chromatographic separation of the enantiomers of a cationic chiral drug (tolperisone) on a heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin column | Authors: | Velmurugan, T. Ching, C.B. Ng, S.C. Bai, Z.W. Ong, T.T. |
Keywords: | β-Cyclodextrin Column liquid chromatography Enantiomer separation Optimizatio Tolperisone |
Issue Date: | 2002 | Citation: | Velmurugan, T.,Ching, C.B.,Ng, S.C.,Bai, Z.W.,Ong, T.T. (2002). Optimization of the reversed-phase high-performance, liquid chromatographic separation of the enantiomers of a cationic chiral drug (tolperisone) on a heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin column. Chromatographia 56 (3-4) : 229-232. ScholarBank@NUS Repository. | Abstract: | Heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin has been synthesized and chemically immobilized on silica gel for use as a chiral stationary phase (PC-CSP) for analytical separation of the enantiomers of chiral drugs. Separation of the enantiomers of tolperisone was studied by high-performance liquid chromatography under reversed-phase conditions. The chromatographic conditions were optimized by varying mobile phase pH, composition, ionic strength, and velocity; 40:60 methanol-1% triethylammonium acetate (TEAA) buffer, pH 5.5, was found to be the most suitable for this separation. | Source Title: | Chromatographia | URI: | http://scholarbank.nus.edu.sg/handle/10635/52671 | ISSN: | 00095893 |
| Appears in Collections: | Staff Publications |
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