Please use this identifier to cite or link to this item:
|Title:||The effects of long-term hormone-replacement therapy on coagulation, fibrinolysis and inhibitors in postmenopausal women|
|Authors:||Koh, S.C.L. |
Shan, Ratnam S.
|Keywords:||Long-term effects of HRT on hemostasis|
|Source:||Koh, S.C.L., Dramusic, V., Shan, Ratnam S. (1998). The effects of long-term hormone-replacement therapy on coagulation, fibrinolysis and inhibitors in postmenopausal women. International Journal of Gynecology and Obstetrics 62 (3) : 279-285. ScholarBank@NUS Repository. https://doi.org/10.1016/S0020-7292(98)00096-4|
|Abstract:||Objective: To study the long-term effects of hormone-replacement therapy (HRT). Methods: Twenty-one menopausal Chinese women who were currently on HRT were studied for the long-term effects of HRT on hemostasis. Another 21 age-matched healthy women not on HRT served as controls. Results: Enhanced thrombin generation was seen in women on long-term HRT. Antithrombin III (ATIII) antigen was significantly reduced but not its activity level and so was FVII. Elevated t-PA activity and u-PA antigen were seen with reduced t-PA antigen. Plasminogen activator inhibitor-1 (PAI-1) levels were significantly reduced together with D-dimer in HRT. Conclusions: Long-term HRT was associated with enhanced thrombin generation and countered by enhanced systemic t-PA activity suggesting an equilibrium state. There was no enhanced cardiovascular risk in long-term HRT as indicated by the observed reduction in t-PA antigen, PAI-1 and FVII levels. However, a larger prospective study is required to confirm these findings.|
|Source Title:||International Journal of Gynecology and Obstetrics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 15, 2018
WEB OF SCIENCETM
checked on Feb 5, 2018
checked on Feb 13, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.