Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0020-7292(98)00096-4
Title: The effects of long-term hormone-replacement therapy on coagulation, fibrinolysis and inhibitors in postmenopausal women
Authors: Koh, S.C.L. 
Dramusic, V. 
Shan, Ratnam S. 
Keywords: Long-term effects of HRT on hemostasis
Issue Date: 1998
Source: Koh, S.C.L., Dramusic, V., Shan, Ratnam S. (1998). The effects of long-term hormone-replacement therapy on coagulation, fibrinolysis and inhibitors in postmenopausal women. International Journal of Gynecology and Obstetrics 62 (3) : 279-285. ScholarBank@NUS Repository. https://doi.org/10.1016/S0020-7292(98)00096-4
Abstract: Objective: To study the long-term effects of hormone-replacement therapy (HRT). Methods: Twenty-one menopausal Chinese women who were currently on HRT were studied for the long-term effects of HRT on hemostasis. Another 21 age-matched healthy women not on HRT served as controls. Results: Enhanced thrombin generation was seen in women on long-term HRT. Antithrombin III (ATIII) antigen was significantly reduced but not its activity level and so was FVII. Elevated t-PA activity and u-PA antigen were seen with reduced t-PA antigen. Plasminogen activator inhibitor-1 (PAI-1) levels were significantly reduced together with D-dimer in HRT. Conclusions: Long-term HRT was associated with enhanced thrombin generation and countered by enhanced systemic t-PA activity suggesting an equilibrium state. There was no enhanced cardiovascular risk in long-term HRT as indicated by the observed reduction in t-PA antigen, PAI-1 and FVII levels. However, a larger prospective study is required to confirm these findings.
Source Title: International Journal of Gynecology and Obstetrics
URI: http://scholarbank.nus.edu.sg/handle/10635/36945
ISSN: 00207292
DOI: 10.1016/S0020-7292(98)00096-4
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

4
checked on Dec 11, 2017

WEB OF SCIENCETM
Citations

5
checked on Dec 11, 2017

Page view(s)

45
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.