Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0020-7292(98)00096-4
DC Field | Value | |
---|---|---|
dc.title | The effects of long-term hormone-replacement therapy on coagulation, fibrinolysis and inhibitors in postmenopausal women | |
dc.contributor.author | Koh, S.C.L. | |
dc.contributor.author | Dramusic, V. | |
dc.contributor.author | Shan, Ratnam S. | |
dc.date.accessioned | 2013-04-10T02:59:16Z | |
dc.date.available | 2013-04-10T02:59:16Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | Koh, S.C.L., Dramusic, V., Shan, Ratnam S. (1998). The effects of long-term hormone-replacement therapy on coagulation, fibrinolysis and inhibitors in postmenopausal women. International Journal of Gynecology and Obstetrics 62 (3) : 279-285. ScholarBank@NUS Repository. https://doi.org/10.1016/S0020-7292(98)00096-4 | |
dc.identifier.issn | 00207292 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/36945 | |
dc.description.abstract | Objective: To study the long-term effects of hormone-replacement therapy (HRT). Methods: Twenty-one menopausal Chinese women who were currently on HRT were studied for the long-term effects of HRT on hemostasis. Another 21 age-matched healthy women not on HRT served as controls. Results: Enhanced thrombin generation was seen in women on long-term HRT. Antithrombin III (ATIII) antigen was significantly reduced but not its activity level and so was FVII. Elevated t-PA activity and u-PA antigen were seen with reduced t-PA antigen. Plasminogen activator inhibitor-1 (PAI-1) levels were significantly reduced together with D-dimer in HRT. Conclusions: Long-term HRT was associated with enhanced thrombin generation and countered by enhanced systemic t-PA activity suggesting an equilibrium state. There was no enhanced cardiovascular risk in long-term HRT as indicated by the observed reduction in t-PA antigen, PAI-1 and FVII levels. However, a larger prospective study is required to confirm these findings. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0020-7292(98)00096-4 | |
dc.source | Scopus | |
dc.subject | Long-term effects of HRT on hemostasis | |
dc.type | Article | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.description.doi | 10.1016/S0020-7292(98)00096-4 | |
dc.description.sourcetitle | International Journal of Gynecology and Obstetrics | |
dc.description.volume | 62 | |
dc.description.issue | 3 | |
dc.description.page | 279-285 | |
dc.description.coden | IJGOA | |
dc.identifier.isiut | 000076097800009 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.