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https://doi.org/10.1007/978-3-031-07634-3_16
Title: | Epigenetic Small-Molecule Modulators Targeting Metabolic Pathways in Cancer | Authors: | Das, D Karthik, N Taneja, R |
Keywords: | Cancer Epigenetics Metabolism Signalling pathways Small molecules Humans Neoplasms Epigenomics Epigenesis, Genetic Metabolic Networks and Pathways |
Issue Date: | 1-Jan-2022 | Publisher: | Springer International Publishing | Citation: | Das, D, Karthik, N, Taneja, R (2022-01-01). Epigenetic Small-Molecule Modulators Targeting Metabolic Pathways in Cancer. Subcell Biochem 100 : 523-555. ScholarBank@NUS Repository. https://doi.org/10.1007/978-3-031-07634-3_16 | Abstract: | Metabolic deregulation is a key factor in cancer progression. Epigenetic changes and metabolic rewiring are intertwined in cancer. Deregulated epigenetic modifiers cause metabolic aberrations by targeting the expression of metabolic enzymes. Conversely, metabolites and cofactors affect the expression and activity of epigenetic regulators. Small molecules are promising therapeutic approaches to target the epigenetic-metabolomic crosstalk in cancer. Here, we focus on the interplay between metabolic rewiring and epigenetic landscape in the context of tumourigenesis and highlight recent advances in the use of small-molecule drug targets for therapy. | Source Title: | Subcell Biochem | URI: | https://scholarbank.nus.edu.sg/handle/10635/234745 | ISSN: | 0306-0225 2542-8810 |
DOI: | 10.1007/978-3-031-07634-3_16 |
Appears in Collections: | Staff Publications Elements |
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Das et al revised 04062021.pdf | 1.75 MB | Adobe PDF | OPEN | None | View/Download |
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