Please use this identifier to cite or link to this item: https://doi.org/10.1007/978-3-031-07634-3_16
Title: Epigenetic Small-Molecule Modulators Targeting Metabolic Pathways in Cancer
Authors: Das, D
Karthik, N 
Taneja, R 
Keywords: Cancer
Epigenetics
Metabolism
Signalling pathways
Small molecules
Humans
Neoplasms
Epigenomics
Epigenesis, Genetic
Metabolic Networks and Pathways
Issue Date: 1-Jan-2022
Publisher: Springer International Publishing
Citation: Das, D, Karthik, N, Taneja, R (2022-01-01). Epigenetic Small-Molecule Modulators Targeting Metabolic Pathways in Cancer. Subcell Biochem 100 : 523-555. ScholarBank@NUS Repository. https://doi.org/10.1007/978-3-031-07634-3_16
Abstract: Metabolic deregulation is a key factor in cancer progression. Epigenetic changes and metabolic rewiring are intertwined in cancer. Deregulated epigenetic modifiers cause metabolic aberrations by targeting the expression of metabolic enzymes. Conversely, metabolites and cofactors affect the expression and activity of epigenetic regulators. Small molecules are promising therapeutic approaches to target the epigenetic-metabolomic crosstalk in cancer. Here, we focus on the interplay between metabolic rewiring and epigenetic landscape in the context of tumourigenesis and highlight recent advances in the use of small-molecule drug targets for therapy.
Source Title: Subcell Biochem
URI: https://scholarbank.nus.edu.sg/handle/10635/234745
ISSN: 0306-0225
2542-8810
DOI: 10.1007/978-3-031-07634-3_16
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