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| Title: | In vitro formation of testosterone via the Δ5-pathway in the human umbilical cord | Authors: | Loganath, A. Gunasegaram, R. Peh, K.L. Chow, W.P. Chew, P.C.T. Shanmugaratnam, S. |
Keywords: | 17α-hydroxylase 17β-hydroxy steroid oxidoreductase 3β-hydroxy steroid dehydrogenase-5,4-ene isomerase androgen synthesis C-17,20-lyase dehydroepiandrosterone fetoplacental unit (umbilical cord) steroids testosterone testosterone synthesis by umbilical cord umbilical cord |
Issue Date: | Apr-1992 | Citation: | Loganath, A., Gunasegaram, R., Peh, K.L., Chow, W.P., Chew, P.C.T., Shanmugaratnam, S. (1992-04). In vitro formation of testosterone via the Δ5-pathway in the human umbilical cord. Steroids 57 (4) : 189-192. ScholarBank@NUS Repository. | Abstract: | Homogenates of two groups of term umbilical cord (n = 6, 37-40 weeks; n = 6, 38-40 weeks) were separately incubated with [7n-3H]pregnenolone and [1,2,6, 7-3H]dehydroepiandrosterone. Using the reverse-isotope dilution technique, [3H]dehydroepiandrosterone and [3H] testosterone formed from the respective substrates were isolated and characterized. The extent of enzymic conversions were 0.015-0.28% and 0.044-2.2%. These results provide evidence for the metabolic transformation of pregnenolone to testosterone via the Δ5-3β-hydroxy route. © 1992. | Source Title: | Steroids | URI: | http://scholarbank.nus.edu.sg/handle/10635/133260 | ISSN: | 0039128X |
| Appears in Collections: | Staff Publications |
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