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Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/133260
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dc.titleIn vitro formation of testosterone via the Δ5-pathway in the human umbilical cord
dc.contributor.authorLoganath, A.
dc.contributor.authorGunasegaram, R.
dc.contributor.authorPeh, K.L.
dc.contributor.authorChow, W.P.
dc.contributor.authorChew, P.C.T.
dc.contributor.authorShanmugaratnam, S.
dc.date.accessioned2016-12-19T06:48:48Z
dc.date.available2016-12-19T06:48:48Z
dc.date.issued1992-04
dc.identifier.citationLoganath, A., Gunasegaram, R., Peh, K.L., Chow, W.P., Chew, P.C.T., Shanmugaratnam, S. (1992-04). In vitro formation of testosterone via the Δ5-pathway in the human umbilical cord. Steroids 57 (4) : 189-192. ScholarBank@NUS Repository.
dc.identifier.issn0039128X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133260
dc.description.abstractHomogenates of two groups of term umbilical cord (n = 6, 37-40 weeks; n = 6, 38-40 weeks) were separately incubated with [7n-3H]pregnenolone and [1,2,6, 7-3H]dehydroepiandrosterone. Using the reverse-isotope dilution technique, [3H]dehydroepiandrosterone and [3H] testosterone formed from the respective substrates were isolated and characterized. The extent of enzymic conversions were 0.015-0.28% and 0.044-2.2%. These results provide evidence for the metabolic transformation of pregnenolone to testosterone via the Δ5-3β-hydroxy route. © 1992.
dc.sourceScopus
dc.subject17α-hydroxylase
dc.subject17β-hydroxy steroid oxidoreductase
dc.subject3β-hydroxy steroid dehydrogenase-5,4-ene isomerase
dc.subjectandrogen synthesis
dc.subjectC-17,20-lyase
dc.subjectdehydroepiandrosterone
dc.subjectfetoplacental unit (umbilical cord)
dc.subjectsteroids
dc.subjecttestosterone
dc.subjecttestosterone synthesis by umbilical cord
dc.subjectumbilical cord
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentBIOCHEMISTRY
dc.description.sourcetitleSteroids
dc.description.volume57
dc.description.issue4
dc.description.page189-192
dc.description.codenSTEDA
dc.identifier.isiutNOT_IN_WOS
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