Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/126229
Title: THE ROLE OF OSTEOGENIC INDUCTION IN BONE TISSUE ENGINEERING AND REGENERATION
Authors: BAO CHAOLEMENG
Keywords: mesenchymal stem cells, osteogenic differentiation, paracrine effect, bone repair, tissue engineering, critical sized defect
Issue Date: 29-Mar-2016
Abstract: Mesenchymal stem cells (MSC) undergo efficient osteogenic differentiation under defined conditions, which underlies their potential in engineering bone grafts for critical-size bone defects. However, the influence of osteogenic induction on MSC’s in-vivo regenerative capacities is yet not clear. Accordingly, a systematic study was designed based on human MSC (hfMSC) loaded three-dimensional biomaterial scaffolds, and the influence of osteogenic induction on the cellular secretome and bone healing efficacy was investigated. The in-vitro evaluations showed that osteogenic induction not only triggered hfMSC differentiation, but also promoted the proangiogenic paracrine activity of the bone grafts (>1.5-fold). Furthermore, a clinically relevant rat bone defect model was created and implanted with induced cellular scaffolds, and the results confirmed that prolonged osteogenic induction led to improved post-transplant neo-vascularization and more robust bone repair (2-fold). In general, this
URI: http://scholarbank.nus.edu.sg/handle/10635/126229
Appears in Collections:Ph.D Theses (Open)

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