Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/126229
DC Field | Value | |
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dc.title | THE ROLE OF OSTEOGENIC INDUCTION IN BONE TISSUE ENGINEERING AND REGENERATION | |
dc.contributor.author | BAO CHAOLEMENG | |
dc.date.accessioned | 2016-08-30T18:00:18Z | |
dc.date.available | 2016-08-30T18:00:18Z | |
dc.date.issued | 2016-03-29 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/126229 | |
dc.description.abstract | Mesenchymal stem cells (MSC) undergo efficient osteogenic differentiation under defined conditions, which underlies their potential in engineering bone grafts for critical-size bone defects. However, the influence of osteogenic induction on MSC’s in-vivo regenerative capacities is yet not clear. Accordingly, a systematic study was designed based on human MSC (hfMSC) loaded three-dimensional biomaterial scaffolds, and the influence of osteogenic induction on the cellular secretome and bone healing efficacy was investigated. The in-vitro evaluations showed that osteogenic induction not only triggered hfMSC differentiation, but also promoted the proangiogenic paracrine activity of the bone grafts (>1.5-fold). Furthermore, a clinically relevant rat bone defect model was created and implanted with induced cellular scaffolds, and the results confirmed that prolonged osteogenic induction led to improved post-transplant neo-vascularization and more robust bone repair (2-fold). In general, this | |
dc.language.iso | en | |
dc.subject | mesenchymal stem cells, osteogenic differentiation, paracrine effect, bone repair, tissue engineering, critical sized defect | |
dc.type | Thesis | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.contributor.supervisor | CHOOLANI, MAHESH A | |
dc.contributor.supervisor | CHAN KOK YEN, JERRY | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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Bao CLM.pdf | 5.57 MB | Adobe PDF | OPEN | None | View/Download |
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