IDENTIFICATION OF 'PHARMA-SNPS' FOR PREDICTING RESPONSE TO DRUG THERAPIES

Abstract

ONE SIZE DOES NOT FIT ALL. DRUG RESPONSE DIFFERENCES, INCLUDING ADVERSE DRUG REACTIONS (ADRS) ARE COMMON PHENOMENON. SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) HAVE BEEN REPORTED TO PLAY SIGNIFICANT ROLE. INITIALLY, I ELUCIDATED THE ARCHITECTURE OF SNPS IN DRUG-RESPONSE GENES, WHICH SHOWED ABUNDANT PRESENCE OF NOT ONLY CODING SNPS, BUT ALSO SNPS IN NON-CODING REGIONS. I THEN PERFORMED A WHOLE GENOME IDENTIFICATION OF SNPS THAT COULD POTENTIALLY BE SIGNIFICANT IN POPULATION DIFFERENTIATION ASSOCIATED WITH VARIOUS PHENOTYPES, INCLUDING DRUG RESPONSE. USING GENOME-WIDE DATA OF 23 MILLION SNPS, POPULATION GENETICS DIFFERENTIATION WAS ESTIMATED USING FST STATISTICS. SUBSEQUENTLY, I GENERATED POPULATION GENETIC PROFILING OF DRUG RESPONSES, AND CONSTRUCTED THE `PHARMA-SNP? WEB RESOURCE THAT PUBLISHES THIS INFORMATION. THE VAST KNOWLEDGE GENERATED IN THIS THESIS IS SIGNIFICANT AS IT CAN BE UTILIZED FOR DEVELOPMENT OF DRUG POPULATION-GENETIC PROFILING FOR THE POTENTIAL IDENTIFICATION OF POPULATIO