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https://scholarbank.nus.edu.sg/handle/10635/117492
DC Field | Value | |
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dc.title | IDENTIFICATION OF 'PHARMA-SNPS' FOR PREDICTING RESPONSE TO DRUG THERAPIES | |
dc.contributor.author | MAULANA BACHTIAR | |
dc.date.accessioned | 2014-12-15T18:00:22Z | |
dc.date.available | 2014-12-15T18:00:22Z | |
dc.date.issued | 2014-08-11 | |
dc.identifier.citation | MAULANA BACHTIAR (2014-08-11). IDENTIFICATION OF 'PHARMA-SNPS' FOR PREDICTING RESPONSE TO DRUG THERAPIES. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/117492 | |
dc.description.abstract | ONE SIZE DOES NOT FIT ALL. DRUG RESPONSE DIFFERENCES, INCLUDING ADVERSE DRUG REACTIONS (ADRS) ARE COMMON PHENOMENON. SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) HAVE BEEN REPORTED TO PLAY SIGNIFICANT ROLE. INITIALLY, I ELUCIDATED THE ARCHITECTURE OF SNPS IN DRUG-RESPONSE GENES, WHICH SHOWED ABUNDANT PRESENCE OF NOT ONLY CODING SNPS, BUT ALSO SNPS IN NON-CODING REGIONS. I THEN PERFORMED A WHOLE GENOME IDENTIFICATION OF SNPS THAT COULD POTENTIALLY BE SIGNIFICANT IN POPULATION DIFFERENTIATION ASSOCIATED WITH VARIOUS PHENOTYPES, INCLUDING DRUG RESPONSE. USING GENOME-WIDE DATA OF 23 MILLION SNPS, POPULATION GENETICS DIFFERENTIATION WAS ESTIMATED USING FST STATISTICS. SUBSEQUENTLY, I GENERATED POPULATION GENETIC PROFILING OF DRUG RESPONSES, AND CONSTRUCTED THE `PHARMA-SNP? WEB RESOURCE THAT PUBLISHES THIS INFORMATION. THE VAST KNOWLEDGE GENERATED IN THIS THESIS IS SIGNIFICANT AS IT CAN BE UTILIZED FOR DEVELOPMENT OF DRUG POPULATION-GENETIC PROFILING FOR THE POTENTIAL IDENTIFICATION OF POPULATIO | |
dc.language.iso | en | |
dc.subject | SNP, Population Differentiation, Pharmacogenomics, 1000 Genome, Pharma-SNP, Genetics | |
dc.type | Thesis | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.supervisor | LEE GUAT LAY, CAROLINE | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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BachtiarM.pdf | 7.26 MB | Adobe PDF | OPEN | None | View/Download |
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