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Title: Human tumour necrosis factors-α and -β: Differences in their structure, expression and biological properties
Authors: Porter, A.G. 
Keywords: Cytokines
Gene transcription
Immune regulation
Issue Date: Nov-1990
Source: Porter, A.G. (1990-11). Human tumour necrosis factors-α and -β: Differences in their structure, expression and biological properties. FEMS Microbiology Letters 64 (4) : 193-199. ScholarBank@NUS Repository.
Abstract: Tumour necrosis factor-α (TNF-α) and lymphotoxin (LT or TNF-β) are cytokines, best known for their cytotoxic or cytostatic effects on some tumour cells. They are structurally related, compete for a common receptor, and are potent inducers of similar biological responses. TNF-α and LT appear to have distinct three-dimensional structures because they differ greatly in their sensitivity to various proteases and chemical agents, and antibodies raised against one cytokine do not cross-react with the other cytokine. The closely linked TNF-α and LT genes are independently regulated since many cell types produce only TNF-α or LT. Expression of the TNF-α gene can be controlled either at the transcriptional or at the post-transcriptional level. In some cell types, TNF-α and LT induce qualitatively or quantitatively different biological responses, and LT can antagonize the action of TNF-α. The disparate biological activities of TNF-α and LT may be related to their different interactions with a common receptor. It is possible that TNF-α and LT have different physiological roles. © 1990.
Source Title: FEMS Microbiology Letters
ISSN: 03781097
Appears in Collections:Staff Publications

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