Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/111924
DC Field | Value | |
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dc.title | Human tumour necrosis factors-α and -β: Differences in their structure, expression and biological properties | |
dc.contributor.author | Porter, A.G. | |
dc.date.accessioned | 2014-11-28T02:51:12Z | |
dc.date.available | 2014-11-28T02:51:12Z | |
dc.date.issued | 1990-11 | |
dc.identifier.citation | Porter, A.G. (1990-11). Human tumour necrosis factors-α and -β: Differences in their structure, expression and biological properties. FEMS Microbiology Letters 64 (4) : 193-199. ScholarBank@NUS Repository. | |
dc.identifier.issn | 03781097 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/111924 | |
dc.description.abstract | Tumour necrosis factor-α (TNF-α) and lymphotoxin (LT or TNF-β) are cytokines, best known for their cytotoxic or cytostatic effects on some tumour cells. They are structurally related, compete for a common receptor, and are potent inducers of similar biological responses. TNF-α and LT appear to have distinct three-dimensional structures because they differ greatly in their sensitivity to various proteases and chemical agents, and antibodies raised against one cytokine do not cross-react with the other cytokine. The closely linked TNF-α and LT genes are independently regulated since many cell types produce only TNF-α or LT. Expression of the TNF-α gene can be controlled either at the transcriptional or at the post-transcriptional level. In some cell types, TNF-α and LT induce qualitatively or quantitatively different biological responses, and LT can antagonize the action of TNF-α. The disparate biological activities of TNF-α and LT may be related to their different interactions with a common receptor. It is possible that TNF-α and LT have different physiological roles. © 1990. | |
dc.source | Scopus | |
dc.subject | Cytokines | |
dc.subject | Cytotoxicity | |
dc.subject | Gene transcription | |
dc.subject | Immune regulation | |
dc.subject | Inflammation | |
dc.subject | Lymphotoxin | |
dc.subject | Receptors | |
dc.type | Article | |
dc.contributor.department | INSTITUTE OF MOLECULAR & CELL BIOLOGY | |
dc.description.sourcetitle | FEMS Microbiology Letters | |
dc.description.volume | 64 | |
dc.description.issue | 4 | |
dc.description.page | 193-199 | |
dc.description.coden | FMLED | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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