Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0036123
Title: LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations
Authors: Wu, Y.R.
Tan, L.C.
Fu, X.
Chen, C.M.
Au, W.L.
Chen, L.
Chen, Y.C.
Prakash, K.M.
Zheng, Y.
Lee-Chen, G.-J.
Zhao, Y.
Zeng, J.-S.
Tan, E.K. 
Pei, Z.
Issue Date: 10-Jul-2012
Citation: Wu, Y.R., Tan, L.C., Fu, X., Chen, C.M., Au, W.L., Chen, L., Chen, Y.C., Prakash, K.M., Zheng, Y., Lee-Chen, G.-J., Zhao, Y., Zeng, J.-S., Tan, E.K., Pei, Z. (2012-07-10). LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations. PLoS ONE 7 (7) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0036123
Abstract: It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population. © 2012 Wu et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/110578
ISSN: 19326203
DOI: 10.1371/journal.pone.0036123
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