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|Title:||GSK3β reduces risk of sporadic Parkinson's disease in ethnic Chinese|
|Citation:||Zhao, D.-M., Li, N.-N., Zhang, J.-H., Chang, X.-L., Mao, X.-Y., Liao, Q., Tan, E.-K., Peng, R. (2012-09). GSK3β reduces risk of sporadic Parkinson's disease in ethnic Chinese. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 159 B (6) : 718-721. ScholarBank@NUS Repository. https://doi.org/10.1002/ajmg.b.32075|
|Abstract:||Genetic variability of glycogen synthase kinase-3β (GSK3β) may be linked to Parkinson's disease (PD). Its role in ethnic Chinese population is still unclear. We examined the association between GSK3β variation and PD in a Han Chinese population from mainland China. Using a case-control methodology, we genotyped the single nucleotide polymorphism (SNP) in GSK3β (rs334558) to investigate the association with risk of PD. A total of 1,280 ethnic Han Chinese study subjects comprising 761 sporadic PD patients and 519 controls were recruited. The T allele of a promoter SNP rs334558 was found to reduce the risk of PD (OR=0.82, 95% CI: 0.696-0.960, P=0.014). Patients with CT+TT genotypes have a reduced risk of PD compared to those with CC genotype (OR=0.61, 95% CI: 0.477-0.776, P=6.09E-5). In addition, we demonstrated that CT+TT subjects cannot be distinguished from CC subjects based on their clinical features. Our data suggest that rs334558 variant in GSK3β reduces the risk of PD in a Han Chinese population from mainland China. Further studies of large series of subjects are necessary to fully elucidate the true role of GSK3β in PD. © 2012 Wiley Periodicals, Inc.|
|Source Title:||American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics|
|Appears in Collections:||Staff Publications|
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