Please use this identifier to cite or link to this item:
Title: Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus
Authors: Tan, E.-K. 
Kwok, H.-K.
Tan, L.C.
Zhao, W.-T.
Prakash, K.M.
Au, W.-L.
Pavanni, R.
Ng, Y.-Y.
Satake, W.
Zhao, Y.
Toda, T.
Liu, J.-J.
Issue Date: 10-Aug-2010
Citation: Tan, E.-K., Kwok, H.-K., Tan, L.C., Zhao, W.-T., Prakash, K.M., Au, W.-L., Pavanni, R., Ng, Y.-Y., Satake, W., Zhao, Y., Toda, T., Liu, J.-J. (2010-08-10). Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus. Neurology 75 (6) : 508-512. ScholarBank@NUS Repository.
Abstract: Objective: A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-linked loci (PARK16, PARK8, PARK1, and BST1) in a Chinese population and also conducted a meta-analysis in Asians by pooling 2 independent replication studies from Japan. Methods: We conducted an analysis of 13 SNPs associated with PD GWAS-linked loci in 2 case-control cohorts comprised of 1,349 ethnic Chinese subjects. Results: PARK16, PARK8, and PARK1 loci but not BST1 were found to be associated with PD. PARK16 SNPs were associated with a decreased risk while PARK1 and PARK8 SNPs were associated with an increased risk of PD. A pooled analysis of our Chinese cohorts and 2 Japanese replication cohorts involving 1,366 subjects with PD and 16,669 controls revealed robust association with these 3 loci and also BST1. There was a trend toward a stronger protective effect of SNPs at the PARK16 locus in sporadic PD compared to familial cases and in older compared to younger subjects. Conclusions: Our study reaffirms the role of GWAS-linked loci in PD in Asian subjects and the strength of association is similar between Chinese and Japanese subjects. Efforts to elucidate the associated gene within PARK16 locus are warranted. © 2010 by AAN Enterprises, Inc. All rights reserved.
Source Title: Neurology
ISSN: 00283878
DOI: 10.1212/WNL.0b013e3181eccfcd
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 16, 2019


checked on Jan 7, 2019

Page view(s)

checked on Dec 21, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.