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|Title:||Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus|
|Authors:||Tan, E.-K. |
|Citation:||Tan, E.-K., Kwok, H.-K., Tan, L.C., Zhao, W.-T., Prakash, K.M., Au, W.-L., Pavanni, R., Ng, Y.-Y., Satake, W., Zhao, Y., Toda, T., Liu, J.-J. (2010-08-10). Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus. Neurology 75 (6) : 508-512. ScholarBank@NUS Repository. https://doi.org/10.1212/WNL.0b013e3181eccfcd|
|Abstract:||Objective: A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-linked loci (PARK16, PARK8, PARK1, and BST1) in a Chinese population and also conducted a meta-analysis in Asians by pooling 2 independent replication studies from Japan. Methods: We conducted an analysis of 13 SNPs associated with PD GWAS-linked loci in 2 case-control cohorts comprised of 1,349 ethnic Chinese subjects. Results: PARK16, PARK8, and PARK1 loci but not BST1 were found to be associated with PD. PARK16 SNPs were associated with a decreased risk while PARK1 and PARK8 SNPs were associated with an increased risk of PD. A pooled analysis of our Chinese cohorts and 2 Japanese replication cohorts involving 1,366 subjects with PD and 16,669 controls revealed robust association with these 3 loci and also BST1. There was a trend toward a stronger protective effect of SNPs at the PARK16 locus in sporadic PD compared to familial cases and in older compared to younger subjects. Conclusions: Our study reaffirms the role of GWAS-linked loci in PD in Asian subjects and the strength of association is similar between Chinese and Japanese subjects. Efforts to elucidate the associated gene within PARK16 locus are warranted. © 2010 by AAN Enterprises, Inc. All rights reserved.|
|Appears in Collections:||Staff Publications|
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