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Title: Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
Authors: Ross, O.A.
Wu, Y.-R.
Lee, M.-C.
Funayama, M.
Chen, M.-L.
Soto, A.I.
Mata, I.F.
Lee-Chen, G.-J.
Chiung, M.C.
Tang, M.
Zhao, Y.
Hattori, N.
Farrer, M.J.
Tan, E.-K. 
Wu, R.-M.
Issue Date: Jul-2008
Citation: Ross, O.A., Wu, Y.-R., Lee, M.-C., Funayama, M., Chen, M.-L., Soto, A.I., Mata, I.F., Lee-Chen, G.-J., Chiung, M.C., Tang, M., Zhao, Y., Hattori, N., Farrer, M.J., Tan, E.-K., Wu, R.-M. (2008-07). Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Annals of Neurology 64 (1) : 88-92. ScholarBank@NUS Repository.
Abstract: Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease. © 2008 American Neurological Association. Published by Wiley-Liss, Inc., through Wiley Subscription Services.
Source Title: Annals of Neurology
ISSN: 03645134
DOI: 10.1002/ana.21405
Appears in Collections:Staff Publications

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