A wireless-compatible optics-free fluorescent array reader

Abstract

Optical-based bioassays, particularly fluorescent-based arrays, form the basis for biological detection in both biological and clinical assays, yet their use is restricted by the need for sensitive optical detectors and optics. To address this, we developed an integrated circuit-based fluorescent imaging platform that functions without the use of optics while directly integrating electronics, enabling a low-cost integrated solution. Additionally, we incorporate a wireless interface, enabling optical detection within any biological environment. As a proof of concept, we demonstrate the detection of 20 nM of Streptavidin on an array without the use of optical filters and lenses. © 2009 American Institute of Physics.