Please use this identifier to cite or link to this item: https://doi.org/10.1103/PhysRevE.79.041926
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dc.titleTemperature dependence of circular DNA topological states
dc.contributor.authorChen, H.
dc.contributor.authorLiu, Y.
dc.contributor.authorZhou, Z.
dc.contributor.authorHu, L.
dc.contributor.authorOu-Yang, Z.-C.
dc.contributor.authorYan, J.
dc.date.accessioned2014-10-16T09:44:23Z
dc.date.available2014-10-16T09:44:23Z
dc.date.issued2009-04-01
dc.identifier.citationChen, H., Liu, Y., Zhou, Z., Hu, L., Ou-Yang, Z.-C., Yan, J. (2009-04-01). Temperature dependence of circular DNA topological states. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 79 (4) : -. ScholarBank@NUS Repository. https://doi.org/10.1103/PhysRevE.79.041926
dc.identifier.issn15393755
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/98218
dc.description.abstractCircular double-stranded DNA has different topological states which are defined by their linking numbers. Equilibrium distribution of linking numbers can be obtained by closing a linear DNA into a circle by ligase. Using Monte Carlo simulation, we predict the temperature dependence of the linking number distribution of small circular DNAs. Our predictions are based on flexible defect excitations that resulted from local melting or unstacking of DNA base pairs. We found that the reduced bending rigidity alone can lead to measurable changes of the variance of linking number distribution of short circular DNAs. If the defect is accompanied by local unwinding, the effect becomes much more prominent. The predictions can be easily investigated in experiments, providing a new method to study the micromechanics of sharply bent DNAs and the thermal stability of specific DNA sequences. Furthermore, the predictions are directly applicable to the studies of binding of DNA-distorting proteins that can locally reduce DNA rigidity, form DNA kinks, or introduce local unwinding. © 2009 The American Physical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1103/PhysRevE.79.041926
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHYSICS
dc.description.doi10.1103/PhysRevE.79.041926
dc.description.sourcetitlePhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
dc.description.volume79
dc.description.issue4
dc.description.page-
dc.description.codenPLEEE
dc.identifier.isiut000265941300120
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