Please use this identifier to cite or link to this item: https://doi.org/10.1385/BTER:108:1-3:215
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dc.titleSelenium and mercury are redistributed to the brain during viral infection in mice
dc.contributor.authorIlbäck, N.-G.
dc.contributor.authorLindh, U.
dc.contributor.authorMinqin, R.
dc.contributor.authorFriman, G.
dc.contributor.authorWatt, F.
dc.date.accessioned2014-10-16T09:40:24Z
dc.date.available2014-10-16T09:40:24Z
dc.date.issued2005-12
dc.identifier.citationIlbäck, N.-G., Lindh, U., Minqin, R., Friman, G., Watt, F. (2005-12). Selenium and mercury are redistributed to the brain during viral infection in mice. Biological Trace Element Research 108 (1-3) : 215-224. ScholarBank@NUS Repository. https://doi.org/10.1385/BTER:108:1-3:215
dc.identifier.issn01634984
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/97880
dc.description.abstractAs part of the general host response to coxsackievirus B3 (CB3) infection, the concentration of essential and nonessential trace elements changes in different target organs of the infection. Essential (e.g., Se) and nonessential (e.g., Hg) trace elements are known to interact and affect inflammatory tissue lesions induced by CB3 infection. However, it is unknown whether these changes involve the brain. In the present study, the brain Hg and Se contents were measured through inductively coupled plasma-mass spectrometry and their distribution investigated by means of nuclear microscopy in the early phase (d 3) of CB3 infection in normally fed female Balb/c mice. Because of the infection, the concentration of Hg (4.07 ± 0.46 ng/g wet wt) and Se (340 ± 16 ng/g wet wt) in the brain increased twofold for Hg (8.77 ± 1.65 ng/g wet wt, p < 0.05) and by 36% for Se (461 ± 150 ng/g wet wt, ns). Nuclear microscopy of brain sections from mice having elevated Se and Hg concentrations failed to find localized levels of the elements high enough to make detection possible, indicating approximately homogeneous tissue distribution. Although the pathophysiological interpretation of these findings requires further research, the increase of Hg in the brain during infection might have an influence on the pathogenesis of the disease. © Copyright 2005 by Humana Press Inc. All rights of any nature, whatsoever, reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1385/BTER:108:1-3:215
dc.sourceScopus
dc.subjectBrain
dc.subjectMass spectrometry
dc.subjectMercury
dc.subjectNuclear microscopy
dc.subjectRedistribution
dc.subjectSelenium
dc.subjectViral infection
dc.typeArticle
dc.contributor.departmentPHYSICS
dc.description.doi10.1385/BTER:108:1-3:215
dc.description.sourcetitleBiological Trace Element Research
dc.description.volume108
dc.description.issue1-3
dc.description.page215-224
dc.description.codenBTERD
dc.identifier.isiut000234115400020
Appears in Collections:Staff Publications

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