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Title: Plant-based hydrocarbon esters from tragia involucrata possess antimicrobial and anti-inflammatory activities
Authors: Samy, R.P. ItemCrisRefDisplayStrategy.rp.deleted.icon
Sethi, G.
Chow, V.T.K.
Stiles, B.G.
Keywords: Antimicrobial
Food-borne bacteria
Skin fibroblasts
Issue Date: 2013
Citation: Samy, R.P.,Sethi, G.,Chow, V.T.K.,Stiles, B.G. (2013). Plant-based hydrocarbon esters from tragia involucrata possess antimicrobial and anti-inflammatory activities. Infectious Disorders - Drug Targets 13 (2) : 141-153. ScholarBank@NUS Repository.
Abstract: Antimicrobial and anti-inflammatory activities of hydrocarbon esters obtained from Tragia involucrata were evaluated by disk-diffusion (250 μg/ml), and broth-dilution (500-7.8 μg/ml), methods against bacteria. Among the compounds, shellsol showed the most potent activity against Burkholderia pseudomallei (KHW), Aeromonas hydrophila, Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Klebsiella pneumoniae, Proteus mirabilis, and Streptococcus pneumoniae. Interestingly, vinyl hexylether was active against food-spoilage bacteria (Bacillus cereus and Proteus vulgaris), 2, 4-methyl hexane also exerted antimicrobial activity against K. pneumoniae, S. pyogenes, B. pseudomallei, Alcaligens viscolactis, and Pseudomonas aeruginosa. 2-methylnonane and 2, 6-dimethyl heptane showed only weak activity. For example, shellsol showed bacteriostatic effect (MIC of 7.8 μg/ml) against A. hydrophila, vinyl hexylether (MIC of 15.6 μg/ml) against P. mirabilis, and 2, 4-methyl hexane (MIC of 31.25 μg/ml) on B. pseudomallei. Cytotoxic effects of compounds were assayed in human skin and monkey kidney cells (62.5-2000 g/ml) by an XTT assay. The vinyl hexylether, 2, 4-dimethyl hexane and shellsol did not show any toxicity up to 1000 μg/ml concentrations. The 2-methylnonane and 2, 6-dimethyl heptane induced morphological changes (e.g. cell disintegration and lysis) of both cell types at a 2000 μg/ml. The vinyl hexylether, 2, 4-dimethyl hexane and shellsol were devoid of toxic effects; however, 2-methylnonane induced weight loss and severe necrosis as evidenced by histopathological and serum biochemical analysis in rats. Interestingly, shellsol showed the maximum inhibition of carrageenan-induced, paw oedema in rats. In conclusion, findings of this study clearly indicate that biologically active hydrocarbon esters, such as shellsol, vinyl hexylether, and 2, 4-dimethyl hexane isolated from T. involucrata, may effectively control the growth of certain food-borne and food-spoilage pathogens. © 2013 Bentham Science Publishers.
Source Title: Infectious Disorders - Drug Targets
ISSN: 18715265
DOI: 10.2174/1871526511313020005
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