Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0168-583X(98)01033-7
DC FieldValue
dc.titleNuclear microscopy in Alzheimer's disease
dc.contributor.authorMakjanic, J.
dc.contributor.authorWatt, F.
dc.date.accessioned2014-10-16T09:34:31Z
dc.date.available2014-10-16T09:34:31Z
dc.date.issued1999-04-02
dc.identifier.citationMakjanic, J., Watt, F. (1999-04-02). Nuclear microscopy in Alzheimer's disease. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 150 (1-4) : 167-172. ScholarBank@NUS Repository. https://doi.org/10.1016/S0168-583X(98)01033-7
dc.identifier.issn0168583X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/97375
dc.description.abstractThe elemental composition of the two types of brain lesions which characterise Alzheimer's disease (AD) has been the subject of intense scrutiny over the last decade, ever since it was proposed that inorganic trace elements, particularly aluminium, might be implicated in the pathogenesis of the disease. The major evidence for this involvement was the detection of aluminium in the characteristic lesions of the AD brain; neuritic plaques and neurofibrillary tangles (NFTs). Using the powerful combination of Particle-Induced X-ray Emission (PIXE), Rutherford Backscattering Spectrometry (RBS) and Scanning Transmission Ion Microscopy (STIM), it is possible to image and analyse structures in brain sections without recourse to chemical staining. Previous results on elemental composition of senile plaques indicated the absence of aluminium at the 15 parts per million level. We have more recently focused on the analysis of neurofibrillary tangles (NFTs), destructive structural defects within neurons. Imaging and analysis of neurons in brain tissue presented a greater challenge due to the small dimensional size compared with the plaques. We describe the methodology and the results of imaging and analysing neurons in brain tissue sections using Nuclear Microscopy. Our results show that aluminium is not present in either neurons or surrounding tissue in unstained sections at the 20 ppm level, but can be observed in stained sections. We also report elemental concentrations showing significant elevations of phosphorus, sulphur, chlorine, iron and zinc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0168-583X(98)01033-7
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHYSICS
dc.description.doi10.1016/S0168-583X(98)01033-7
dc.description.sourcetitleNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
dc.description.volume150
dc.description.issue1-4
dc.description.page167-172
dc.description.codenNIMBE
dc.identifier.isiut000080056500029
Appears in Collections:Staff Publications

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