Please use this identifier to cite or link to this item: https://doi.org/10.1103/PhysRevA.46.8002
Title: Modified self-consistent phonon calculation of the dependence of DNA melting temperature on guanine-cytosine content
Authors: Feng, Y. 
Tan, S.C. 
Issue Date: 1992
Citation: Feng, Y., Tan, S.C. (1992). Modified self-consistent phonon calculation of the dependence of DNA melting temperature on guanine-cytosine content. Physical Review A 46 (12) : 8002-8006. ScholarBank@NUS Repository. https://doi.org/10.1103/PhysRevA.46.8002
Abstract: We have modified the self-consistent phonon approach to treat DNA double helices modeled with a large repeating unit (N base pairs) so that melting behaviors of DNA polymers of various base-pair sequences can be studied. The melting temperatures of DNA polymers of different G-C-to-A-T ratios were calculated (G, C, A, and T denote guanine, cytosine, adenine, and thymine, respectively). It is shown that a DNA polymer with a relatively higher content of A-T melts at a lower temperature than DNA with a higher content of G-C. The melting temperature increases linearly when the G-C content in a DNA polymer increases. This is in agreement with both experimental observations and theoretical analysis. © 1992 The American Physical Society.
Source Title: Physical Review A
URI: http://scholarbank.nus.edu.sg/handle/10635/97241
ISSN: 10502947
DOI: 10.1103/PhysRevA.46.8002
Appears in Collections:Staff Publications

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