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|Title:||Modified self-consistent phonon calculation of the dependence of DNA melting temperature on guanine-cytosine content||Authors:||Feng, Y.
|Issue Date:||1992||Citation:||Feng, Y., Tan, S.C. (1992). Modified self-consistent phonon calculation of the dependence of DNA melting temperature on guanine-cytosine content. Physical Review A 46 (12) : 8002-8006. ScholarBank@NUS Repository. https://doi.org/10.1103/PhysRevA.46.8002||Abstract:||We have modified the self-consistent phonon approach to treat DNA double helices modeled with a large repeating unit (N base pairs) so that melting behaviors of DNA polymers of various base-pair sequences can be studied. The melting temperatures of DNA polymers of different G-C-to-A-T ratios were calculated (G, C, A, and T denote guanine, cytosine, adenine, and thymine, respectively). It is shown that a DNA polymer with a relatively higher content of A-T melts at a lower temperature than DNA with a higher content of G-C. The melting temperature increases linearly when the G-C content in a DNA polymer increases. This is in agreement with both experimental observations and theoretical analysis. © 1992 The American Physical Society.||Source Title:||Physical Review A||URI:||http://scholarbank.nus.edu.sg/handle/10635/97241||ISSN:||10502947||DOI:||10.1103/PhysRevA.46.8002|
|Appears in Collections:||Staff Publications|
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