Please use this identifier to cite or link to this item: https://doi.org/10.1063/1.4740231
Title: High throughput fabrication of disposable nanofluidic lab-on-chip devices for single molecule studies
Authors: van Kan, J.A. 
Zhang, C.
Perumal Malar, P. 
van der Maarel, J.R.C. 
Issue Date: 18-Jul-2012
Citation: van Kan, J.A., Zhang, C., Perumal Malar, P., van der Maarel, J.R.C. (2012-07-18). High throughput fabrication of disposable nanofluidic lab-on-chip devices for single molecule studies. Biomicrofluidics 6 (3) : -. ScholarBank@NUS Repository. https://doi.org/10.1063/1.4740231
Abstract: An easy method is introduced allowing fast polydimethylsiloxane (PDMS) replication of nanofluidic lab-on-chip devices using accurately fabricated molds featuring cross-sections down to 60 nm. A high quality master is obtained through proton beam writing and UV lithography. This master can be used more than 200 times to replicate nanofluidic devices capable of handling single DNA molecules. This method allows to fabricate nanofluidic devices through simple PDMS casting. The extensions of YOYO-1 stained bacteriophage T4 and λ-DNA inside these nanochannels have been investigated using fluorescence microscopy and follow the scaling prediction of a large, locally coiled polymer chain confined in nanochannels. © 2012 American Institute of Physics.
Source Title: Biomicrofluidics
URI: http://scholarbank.nus.edu.sg/handle/10635/96799
ISSN: 19321058
DOI: 10.1063/1.4740231
Appears in Collections:Staff Publications

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