Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0039-9140(97)00297-X
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dc.titleDetermination of lead in blood by hydrodynamic voltammetry in a flow injection system with wall-jet detector
dc.contributor.authorJaenicke, S.
dc.contributor.authorSabarathinam, R.M.
dc.contributor.authorFleet, B.
dc.contributor.authorGunasingham, H.
dc.date.accessioned2014-10-16T08:47:58Z
dc.date.available2014-10-16T08:47:58Z
dc.date.issued1998-02
dc.identifier.citationJaenicke, S., Sabarathinam, R.M., Fleet, B., Gunasingham, H. (1998-02). Determination of lead in blood by hydrodynamic voltammetry in a flow injection system with wall-jet detector. Talanta 45 (4) : 703-711. ScholarBank@NUS Repository. https://doi.org/10.1016/S0039-9140(97)00297-X
dc.identifier.issn00399140
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95449
dc.description.abstractLead is one of the most widely distributed toxic heavy metals in the environment. It is a cumulative poison, affecting the brain and nervous system. The threshold between the normal lead level and the level where physiological effects become manifest is relatively narrow. It is therefore desirable to screen exposed populations in order to identify the danger in time. The lead concentration in the blood is a measure to the total amount of lead in the body. A fast, accurate and cheap method for the determination of lead in blood is therefore needed. The conventional method used to determine lead in blood is atomic absorption. Electrochemical methods like stripping voltammetry combine high analytical sensitivity with relatively low cost for the equipment; however, electrode preparation is critical for the success of an analysis, and highly skilled personnel are needed. We describe an automated electrochemical method, using flow injection analysis with a wall-jet detector. Lead is released from its binding site in the blood by ion exchange and quantified by stripping voltammetry with a mercury film electrode (MFE). The method allows for the detection of 0.05 ppm Pb2+ with an accuracy of about 10% Electrode poisoning by proteins from the blood can be effectively suppressed when a MFE modified with a Nafion®-membrane coating is used. Such modified electrodes can be activated in the solution without further treatment, and used for more than 100 analyses before they have to be replaced. A solid matrix MFE with a Nation®-membrane and all necessary chemicals for mercury film formation and lead release has been developed. Such electrodes are discussed as disposable electrodes for a portable blood lead detector.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0039-9140(97)00297-X
dc.sourceScopus
dc.subjectAnodic stripping voltammetry
dc.subjectBlood analysis
dc.subjectLead
dc.subjectMercury film electrode
dc.subjectWall-jet cell
dc.typeConference Paper
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/S0039-9140(97)00297-X
dc.description.sourcetitleTalanta
dc.description.volume45
dc.description.issue4
dc.description.page703-711
dc.description.codenTLNTA
dc.identifier.isiut000072165000012
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