Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00775-012-0923-y
DC FieldValue
dc.title[Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O is 2,6-dipicolinate and N,O is L-threoninate: Synthesis, characterization, and biomedical properties
dc.contributor.authorChin, L.-F.
dc.contributor.authorKong, S.-M.
dc.contributor.authorSeng, H.-L.
dc.contributor.authorTiong, Y.-L.
dc.contributor.authorNeo, K.-E.
dc.contributor.authorMaah, M.J.
dc.contributor.authorKhoo, A.S.-B.
dc.contributor.authorAhmad, M.
dc.contributor.authorHor, T.-S.A.
dc.contributor.authorLee, H.-B.
dc.contributor.authorSan, S.-L.
dc.contributor.authorChye, S.-M.
dc.contributor.authorNg, C.-H.
dc.date.accessioned2014-10-16T08:47:49Z
dc.date.available2014-10-16T08:47:49Z
dc.date.issued2012-10
dc.identifier.citationChin, L.-F., Kong, S.-M., Seng, H.-L., Tiong, Y.-L., Neo, K.-E., Maah, M.J., Khoo, A.S.-B., Ahmad, M., Hor, T.-S.A., Lee, H.-B., San, S.-L., Chye, S.-M., Ng, C.-H. (2012-10). [Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O is 2,6-dipicolinate and N,O is L-threoninate: Synthesis, characterization, and biomedical properties. Journal of Biological Inorganic Chemistry 17 (7) : 1093-1105. ScholarBank@NUS Repository. https://doi.org/10.1007/s00775-012-0923-y
dc.identifier.issn09498257
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95435
dc.description.abstractTwo ternary Zn(II) complexes, with 1,10-phenanthroline (phen) as the main ligand and a carboxylatecontaining ligand [dipicolinate (dipico) or L-threoninate (L-Thr)] as the subsidiary ligand, were prepared and characterized by elemental analysis, Fourier transform IR, UV, and fluorescence spectroscopy, X-ray diffraction, molar conductivity, and electrospray ionization mass spectrometry. X-ray structure analysis shows that both [Zn(phen)(dipico)(H 2O)]·H2O (1) and [Zn(phen)(L-Thr)(H 2O)Cl] ·2H2O (2) have octahedral geometry about the Zn(II) atom. Both complexes can inhibit topoisomerase I, and have better anticancer activity than cisplatin against nasopharyngeal cancer cell lines, HK1 and HONE-1, with concentrations causing 50 % inhibition of cell proliferation (IC50) in the low micromolar range. Complex 2 has the highest therapeutic index for HK1. Both Zn(II) complexes can induce cell death by apoptosis. Changing the subsidiary ligand in the Zn(II) complexes affects the UV-fluorescence spectral properties of the coordinated phen ligand, the binding affinity for some DNA sequences, nucleobase sequenceselective binding, the phase at which cell cycle progression was arrested for treated cancer cells, and their therapeutic index. © SBIC 2012.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00775-012-0923-y
dc.sourceScopus
dc.subjectDipicolinic acid
dc.subjectL-Threonine
dc.subjectNasopharyngeal carcinoma
dc.subjectTernary zinc(II)-1, 10-phenanthroline complex
dc.subjectTopoisomerase I
dc.typeConference Paper
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1007/s00775-012-0923-y
dc.description.sourcetitleJournal of Biological Inorganic Chemistry
dc.description.volume17
dc.description.issue7
dc.description.page1093-1105
dc.description.codenJJBCF
dc.identifier.isiut000308819200011
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

11
checked on Nov 27, 2020

WEB OF SCIENCETM
Citations

11
checked on Nov 27, 2020

Page view(s)

85
checked on Nov 22, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.